The influence on skin penetration by dithranol formulated in phospholipid solutions and phospholipid liposomes

W. Gehring, M. Ghyczy, J. Gareiss, M. Gloor

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Dithranol 0.5% was applied occlusively for 10 min to the healthy skin of 10 volunteers in three anhydrous, nonliposomal phospholipid formulations and in one phospholipid liposome base. The development of dithranol erythema was monitored chromametrically and by laser Doppler flowmetry after 24, 48, and 72 h. A potentiation of the dithranol erythema was only detected for the liposomal formulation. The penetration-promoting effect for dithranol was attributed to the liposomal structure and not to the phospholipid content.

Original languageEnglish
Pages (from-to)140-142
Number of pages3
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume41
Issue number2
Publication statusPublished - Jan 1 1995

Keywords

  • dithranol
  • irritation
  • non-liposomal phospholipids
  • penetration promotion
  • phospholipid liposomes

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

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