The influence of synthetic modifications in ring C of morphine on opioid activity and receptor sensitivity

S. Fürst, T. Friedmann, S. Hosztafi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

6-azido-substituted dihydroisomorphine derivatives proved to be 40-800 times more potent analgesics than their parent molecules. The agonist effects appeared to be mediated by μ receptor, since they were readily antagonized by naloxone. The N-substituted members were found to act as μ antagonists or mixed μ antagonist/κ agonists.

Original languageEnglish
Title of host publicationNew leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914
EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
PublisherElsevier Science Publishers B.V.
Pages76-77
Number of pages2
ISBN (Print)044481213X
Publication statusPublished - 1990
EventThe International Narcotics Research Conference -
Duration: Jul 8 1989Jul 13 1989

Other

OtherThe International Narcotics Research Conference
Period7/8/897/13/89

Fingerprint

Opioid Receptors
Naloxone
Morphine
Analgesics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fürst, S., Friedmann, T., & Hosztafi, S. (1990). The influence of synthetic modifications in ring C of morphine on opioid activity and receptor sensitivity. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, ... T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (pp. 76-77). Elsevier Science Publishers B.V..

The influence of synthetic modifications in ring C of morphine on opioid activity and receptor sensitivity. / Fürst, S.; Friedmann, T.; Hosztafi, S.

New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. ed. / J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus; J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. p. 76-77.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fürst, S, Friedmann, T & Hosztafi, S 1990, The influence of synthetic modifications in ring C of morphine on opioid activity and receptor sensitivity. in JM Van Ree, AH Mulder, VM Wiegant, TB Van Wimersma Greidanus, JM Van Ree, AH Mulder, VM Wiegant & TB Van Wimersma Greidanus (eds), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Elsevier Science Publishers B.V., pp. 76-77, The International Narcotics Research Conference, 7/8/89.
Fürst S, Friedmann T, Hosztafi S. The influence of synthetic modifications in ring C of morphine on opioid activity and receptor sensitivity. In Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, editors, New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Elsevier Science Publishers B.V. 1990. p. 76-77
Fürst, S. ; Friedmann, T. ; Hosztafi, S. / The influence of synthetic modifications in ring C of morphine on opioid activity and receptor sensitivity. New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. editor / J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus ; J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. pp. 76-77
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