The influence of polyvinylpyrrolidone on furosemide complexation with randomly-methylated-β-cyclodextrin

Codruţa Şoica, Árpad Gyéresi, Z. Aigner, Mihaly Kata, Cristina Dehelean

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The combined effect of randomly-methylated-â-cyclodextrin (RAMEB) and polyvinylpyrrolidone (PVP) on the solubility of furosemide (FS) was studied. Different molar ratios (1:1, 1:2) and various preparation methods (physical mixing, kneading, ultrasonication) were used for the preparation of the complexes, and a quantity of 15% of PVP was added. The ternary inclusion complexes were analyzed by in vitro dissolution tests, differential scanning calorimetry, in vitro membrane diffusion and X-ray diffraction. The presence of RAMEB and PVP strongly influences different parameters of furosemide: solubility, dissolution, leading to the possibility of obtaining new pharmaceutical preparations, with a greater bioavailability.

Original languageEnglish
Pages (from-to)726-730
Number of pages5
JournalRevista de Chimie
Volume57
Issue number7
Publication statusPublished - Jul 2006

Fingerprint

Povidone
Cyclodextrins
Furosemide
Complexation
Dissolution
Solubility
Drug products
Differential scanning calorimetry
Membranes
X ray diffraction
Pharmaceutical Preparations
Biological Availability

Keywords

  • Bioavailability
  • Furosemide
  • PVP
  • RAMEB
  • Solubility

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

The influence of polyvinylpyrrolidone on furosemide complexation with randomly-methylated-β-cyclodextrin. / Şoica, Codruţa; Gyéresi, Árpad; Aigner, Z.; Kata, Mihaly; Dehelean, Cristina.

In: Revista de Chimie, Vol. 57, No. 7, 07.2006, p. 726-730.

Research output: Contribution to journalArticle

Şoica, Codruţa ; Gyéresi, Árpad ; Aigner, Z. ; Kata, Mihaly ; Dehelean, Cristina. / The influence of polyvinylpyrrolidone on furosemide complexation with randomly-methylated-β-cyclodextrin. In: Revista de Chimie. 2006 ; Vol. 57, No. 7. pp. 726-730.
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