The influence of polymers on the physical stability and the thermal properties of dimyristoyl-phosphatidylcholine liposomes

F. L. Grohmann, Ferenc Csempesz, M. Szögyi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of some neutral polymers on the physical stability of dimyristoyl-phosphatidylcholine(DMPC)-liposomes and on the phase transition parameters of the phospholipid membrane was studied by size distribution measurements and differential scanning calorimetry. It was shown that uncharged macromolecules can be effective steric stabilizers for the vesicles. A close correlation was found between the thickness of the polymer layer formed around the vesicles and the physical stability of the liposomes. DSC measurements confirmed that the macromolecules interact with the membrane bilayer. The best steric stabilizer, poly(vinyl alcohol-co-vinyl butyral)copolymer eliminates pretransition of the membrane.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalPharmazie
Volume54
Issue number1
Publication statusPublished - Jan 1 1999

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'The influence of polymers on the physical stability and the thermal properties of dimyristoyl-phosphatidylcholine liposomes'. Together they form a unique fingerprint.

  • Cite this