The effect of some neutral polymers on the physical stability of dimyristoyl-phosphatidylcholine(DMPC)-liposomes and on the phase transition parameters of the phospholipid membrane was studied by size distribution measurements and differential scanning calorimetry. It was shown that uncharged macromolecules can be effective steric stabilizers for the vesicles. A close correlation was found between the thickness of the polymer layer formed around the vesicles and the physical stability of the liposomes. DSC measurements confirmed that the macromolecules interact with the membrane bilayer. The best steric stabilizer, poly(vinyl alcohol-co-vinyl butyral)copolymer eliminates pretransition of the membrane.
|Number of pages||4|
|Publication status||Published - Jan 1 1999|
ASJC Scopus subject areas
- Pharmaceutical Science