The influence of oxytocin on the steady-state level and accumulation of serotonin in rat brain regions

Helmut Schwarzberg, Gábor L. Kovács, Gyula Teledgy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of graded amounts of centrally injected /intracerebroventricular, i.c.v./ oxytocin /OXT/ have been studied on the steady-state level and pargyline-induced accumulation of serotonin /5-HT/ in the hypothalamus, mesencephalon and dorsal hippocampus of rats. OXT only weakly affected the steady-state level of 5-HT. The pargyline-induced accumulation, on the other hand, was inhibited by central OXT treatment. Whereas OXT inhibited 5-HT accumulation in a dose-dependent manner in the hypothalamus, only the lowest amount of OXT was effective in the mesencephalon and the dorsal hippocampus. The data raise the possibility that an altered 5-HT metabolism is likely to have functional significance in the endocrine and behavioral effects of OXT.

Original languageEnglish
Pages (from-to)145-156
Number of pages12
JournalNeuropeptides
Volume4
Issue number2
DOIs
Publication statusPublished - Mar 1984

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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