In rats 1 mg/kg naloxone significantly delayed the development and decreased the duration of the loss of righting reflex caused by 35 mg/kg intraperitoneally, or subcutaneously administered pentobarbital or by the same dose of intraperitoneally injected methohexital. Naloxone also antagonized the toxicity of 50-125 mg/kg intraperitoneally administered pentobarbital and increased the LD50 of pentobarbital from 59.0 (50.0-69.6) to 101.1 (85.5-119.1) mg/kg. The findings of this study indicate that therapeutic trials with relatively large doses of naloxone are justifiable in patients intoxicated with barbiturates.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)