The influence of naloxone on barbiturate anesthesia and toxicity in the rat

Z. Fürst, F. F. Foldes, J. Knoll

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37 Citations (Scopus)

Abstract

In rats 1 mg/kg naloxone significantly delayed the development and decreased the duration of the loss of righting reflex caused by 35 mg/kg intraperitoneally, or subcutaneously administered pentobarbital or by the same dose of intraperitoneally injected methohexital. Naloxone also antagonized the toxicity of 50-125 mg/kg intraperitoneally administered pentobarbital and increased the LD50 of pentobarbital from 59.0 (50.0-69.6) to 101.1 (85.5-119.1) mg/kg. The findings of this study indicate that therapeutic trials with relatively large doses of naloxone are justifiable in patients intoxicated with barbiturates.

Original languageEnglish
Pages (from-to)921-926
Number of pages6
JournalLife Sciences
Volume20
Issue number6
DOIs
Publication statusPublished - Mar 15 1977

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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