The influence of molecular structure and crystallization time on the efficiency of diastereoisomeric salt forming resolutions

Emese Pálovics, J. Schindler, F. Faigl, E. Fogassy

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Reciprocal resolutions between compounds (racemates and enantiomers) with similar structures have been examined. Amongst structurally similar compounds (so called relative structures) several N-acyl amino acids and amino acid esters were investigated. A part of the resolving agent or the racemic compound could be replaced by an achiral compound with a relative structure and an additive could occasionally improve significantly the efficiency of the resolution. Both the kinetic and the thermodynamic controls were observed as governing factors of the reciprocal resolutions.

Original languageEnglish
Pages (from-to)2429-2434
Number of pages6
JournalTetrahedron Asymmetry
Volume21
Issue number19
DOIs
Publication statusPublished - Oct 7 2010

Fingerprint

Crystallization
Molecular structure
Amino acids
molecular structure
Salts
crystallization
salts
Amino Acids
amino acids
Enantiomers
Esters
enantiomers
Thermodynamics
Kinetics
esters
thermodynamics
acids
kinetics

ASJC Scopus subject areas

  • Organic Chemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Catalysis

Cite this

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AU - Faigl, F.

AU - Fogassy, E.

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