The influence of Metolose structure on the free volume and the consequent metoprolol tartrate release of patches

József Papp, Sylvia Marton, K. Süvegh, R. Zelkó

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Matrix-type patches containing Metoprolol tartrate were prepared from two types of Metolose and acrylate polymers. Metolose SM 4000 and Metolose 90SH 100.000SR were applied in different proportions in the patches where the total polymer content was kept constant in each sample. The purpose of the study was to investigate the effect of Metolose structure on the free volume of the patches and the consequent drug release profile. The drug release profiles were characterized by zero-order and first-order models. The results indicate that Metolose, containing hydroxypropyl ether groups and methyl ether groups, enables the formation of H-bonds, thus increasing the free volume holes and the consequent extent and rate of drug release of patches.

Original languageEnglish
Pages (from-to)6-8
Number of pages3
JournalInternational Journal of Biological Macromolecules
Volume44
Issue number1
DOIs
Publication statusPublished - Jan 1 2009

Fingerprint

Metoprolol
Free volume
Polymers
Pharmaceutical Preparations
Methyl Ethers
Ether
Drug Liberation

Keywords

  • Drug release profile
  • Metolose
  • Positron annihilation lifetime spectroscopy

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Cite this

The influence of Metolose structure on the free volume and the consequent metoprolol tartrate release of patches. / Papp, József; Marton, Sylvia; Süvegh, K.; Zelkó, R.

In: International Journal of Biological Macromolecules, Vol. 44, No. 1, 01.01.2009, p. 6-8.

Research output: Contribution to journalArticle

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