The influence of cadmium on the biliary excretion of eosine and bromsulphthalein and on microsomal monooxygenase activities in the rat

F. Jahn, Z. Gregus, A. Gyurasics, F. Varga, W. Klinger

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Abstract

Cadmium sulfate x 8/3 H2O (0.3, 0.6, 1.5 and 2.0 mg/kg) administered simultaneously with eosine and bromsulphthalein (120 μmol/kg i.v.) did not significantly change the biliary excretion of the dyes. After a 3 day pretreatment with 2.0 mg/kg CdSO4 i.p., a body weight loss and an increase in the relative liver weight when calculated on body weight were observed together with an enhanced bile flow, but the excretion of the dyes was not markedly influenced. Ethylmorphine N-demethylation and ethoxycoumarin O-deethylation activities, as well as microsomal cytochrome P-450 concentration, were diminished by about 50%. It can be concluded that in male rats the hepatic microsomal monooxygenase system is more sensitive towards cadmium than the hepatic transport system for organic anions.

Original languageEnglish
Pages (from-to)255-261
Number of pages7
JournalActa biologica et medica Germanica
Volume41
Issue number2-3
Publication statusPublished - Dec 1 1982

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ASJC Scopus subject areas

  • Medicine(all)

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