Furosemide (F) is practically insoluble in water (10.26 mg/100 mL). Different β-cyclodextrins (β-CD derivatives) were applied as host to improve the solubility of furosemide as guest molecule via inclusion complex formation. Various molar ratios of F: β-CD derivatives (1:1/2, 1:1 and 1:2) and different preparative methods (physical mixing, kneading, precipitation, spray-drying and freeze-drying) were used. The increase in the dissolution characteristics and the solubility of furosemide depends on the type of β-CD derivative, on the furosemide concentration in the product and on the method of preparation. The inclusion complexes formed between the hosts and the guest were investigated by XRD, IR, and 1H-NMR spectral methods.
|Number of pages||8|
|Journal||Journal of Inclusion Phenomena and Molecular Recognition in Chemistry|
|Publication status||Published - Jul 1998|
- Inclusion complexes
ASJC Scopus subject areas
- Food Science
- Condensed Matter Physics