The influence of β-cyclodextrins on the solubility of furosemide

R. M. Amin Kreaz, G. Y. Dombi, M. Kata

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Furosemide (F) is practically insoluble in water (10.26 mg/100 mL). Different β-cyclodextrins (β-CD derivatives) were applied as host to improve the solubility of furosemide as guest molecule via inclusion complex formation. Various molar ratios of F: β-CD derivatives (1:1/2, 1:1 and 1:2) and different preparative methods (physical mixing, kneading, precipitation, spray-drying and freeze-drying) were used. The increase in the dissolution characteristics and the solubility of furosemide depends on the type of β-CD derivative, on the furosemide concentration in the product and on the method of preparation. The inclusion complexes formed between the hosts and the guest were investigated by XRD, IR, and 1H-NMR spectral methods.

Original languageEnglish
Pages (from-to)189-196
Number of pages8
JournalJournal of Inclusion Phenomena and Molecular Recognition in Chemistry
Volume31
Issue number3
DOIs
Publication statusPublished - Jul 1998

    Fingerprint

Keywords

  • Cyclodextrins
  • Furosemide
  • Inclusion complexes
  • Solubility

ASJC Scopus subject areas

  • Food Science
  • Chemistry(all)
  • Condensed Matter Physics

Cite this