The influence of β-cyclodextrins on the solubility of furosemide

R. M. Amin Kreaz, G. Dombi, M. Kata

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Furosemide (F) is practically insoluble in water (10.26 mg/100 mL). Different β-cyclodextrins (β-CD derivatives) were applied as host to improve the solubility of furosemide as guest molecule via inclusion complex formation. Various molar ratios of F: β-CD derivatives (1:1/2, 1:1 and 1:2) and different preparative methods (physical mixing, kneading, precipitation, spray-drying and freeze-drying) were used. The increase in the dissolution characteristics and the solubility of furosemide depends on the type of β-CD derivative, on the furosemide concentration in the product and on the method of preparation. The inclusion complexes formed between the hosts and the guest were investigated by XRD, IR, and 1H-NMR spectral methods.

Original languageEnglish
Pages (from-to)189-196
Number of pages8
JournalJournal of Inclusion Phenomena and Molecular Recognition in Chemistry
Volume31
Issue number3
Publication statusPublished - Jul 1998

Fingerprint

furosemide
cyclodextrins
Furosemide
Cyclodextrins
Solubility
solubility
inclusions
freeze drying
chemical derivatives
spectral methods
Derivatives
drying
sprayers
dissolving
kneading
Spray drying
preparation
nuclear magnetic resonance
Freeze Drying
spray drying

Keywords

  • Cyclodextrins
  • Furosemide
  • Inclusion complexes
  • Solubility

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

The influence of β-cyclodextrins on the solubility of furosemide. / Amin Kreaz, R. M.; Dombi, G.; Kata, M.

In: Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, Vol. 31, No. 3, 07.1998, p. 189-196.

Research output: Contribution to journalArticle

@article{38b6aefc9d1b4ee5baf4942a558e40a8,
title = "The influence of β-cyclodextrins on the solubility of furosemide",
abstract = "Furosemide (F) is practically insoluble in water (10.26 mg/100 mL). Different β-cyclodextrins (β-CD derivatives) were applied as host to improve the solubility of furosemide as guest molecule via inclusion complex formation. Various molar ratios of F: β-CD derivatives (1:1/2, 1:1 and 1:2) and different preparative methods (physical mixing, kneading, precipitation, spray-drying and freeze-drying) were used. The increase in the dissolution characteristics and the solubility of furosemide depends on the type of β-CD derivative, on the furosemide concentration in the product and on the method of preparation. The inclusion complexes formed between the hosts and the guest were investigated by XRD, IR, and 1H-NMR spectral methods.",
keywords = "Cyclodextrins, Furosemide, Inclusion complexes, Solubility",
author = "{Amin Kreaz}, {R. M.} and G. Dombi and M. Kata",
year = "1998",
month = "7",
language = "English",
volume = "31",
pages = "189--196",
journal = "Journal of Inclusion Phenomena and Macrocyclic Chemistry",
issn = "0923-0750",
publisher = "Kluwer Academic Publishers",
number = "3",

}

TY - JOUR

T1 - The influence of β-cyclodextrins on the solubility of furosemide

AU - Amin Kreaz, R. M.

AU - Dombi, G.

AU - Kata, M.

PY - 1998/7

Y1 - 1998/7

N2 - Furosemide (F) is practically insoluble in water (10.26 mg/100 mL). Different β-cyclodextrins (β-CD derivatives) were applied as host to improve the solubility of furosemide as guest molecule via inclusion complex formation. Various molar ratios of F: β-CD derivatives (1:1/2, 1:1 and 1:2) and different preparative methods (physical mixing, kneading, precipitation, spray-drying and freeze-drying) were used. The increase in the dissolution characteristics and the solubility of furosemide depends on the type of β-CD derivative, on the furosemide concentration in the product and on the method of preparation. The inclusion complexes formed between the hosts and the guest were investigated by XRD, IR, and 1H-NMR spectral methods.

AB - Furosemide (F) is practically insoluble in water (10.26 mg/100 mL). Different β-cyclodextrins (β-CD derivatives) were applied as host to improve the solubility of furosemide as guest molecule via inclusion complex formation. Various molar ratios of F: β-CD derivatives (1:1/2, 1:1 and 1:2) and different preparative methods (physical mixing, kneading, precipitation, spray-drying and freeze-drying) were used. The increase in the dissolution characteristics and the solubility of furosemide depends on the type of β-CD derivative, on the furosemide concentration in the product and on the method of preparation. The inclusion complexes formed between the hosts and the guest were investigated by XRD, IR, and 1H-NMR spectral methods.

KW - Cyclodextrins

KW - Furosemide

KW - Inclusion complexes

KW - Solubility

UR - http://www.scopus.com/inward/record.url?scp=0008988686&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0008988686&partnerID=8YFLogxK

M3 - Article

VL - 31

SP - 189

EP - 196

JO - Journal of Inclusion Phenomena and Macrocyclic Chemistry

JF - Journal of Inclusion Phenomena and Macrocyclic Chemistry

SN - 0923-0750

IS - 3

ER -