Die induktion oraler toleranz: Eine neue therapiestrategie für autoimmunerkrankungen?

Translated title of the contribution: The induction of oral tolerance: A new therapeutical strategy for the treatment of autoimmune diseases?

Research output: Contribution to journalArticle

Abstract

The phenomenon of oral tolerance (the state of systemic hyporesponsiveness after oral antigen delivery) has been known for a long time; nevertheless it turned out only in the last decades that it could be used for the treatment of autoimmune diseases. The induction of oral tolerance was shown to be very effective for the prevention of disease development in numerous animal models of human autoimmune diseases, and to a lesser extent for the alleviation of symptoms in already ill animals. As opposed to these promising experiments, no such considerable results were found in human trials. In this review, I will try to summarize the present status of these experiments and to discuss the possible advantages and disadvantages of this therapeutic protocol.

Original languageGerman
Pages (from-to)440-443
Number of pages4
JournalWiener Medizinische Wochenschrift
Volume150
Issue number22
Publication statusPublished - 2000

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Autoimmune Diseases
Animal Models
Antigens
Therapeutics

Keywords

  • Antigens
  • Autoimmune diseases
  • Cytokines
  • Oral tolerance
  • T-cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Die induktion oraler toleranz : Eine neue therapiestrategie für autoimmunerkrankungen? / Igaz, P.

In: Wiener Medizinische Wochenschrift, Vol. 150, No. 22, 2000, p. 440-443.

Research output: Contribution to journalArticle

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