The incorporation of citrate carbon into fatty acids

Amar Bhaduri, P. Srere

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Long-chain fatty acids are synthesized from citrate in an undialyzed soluble enzyme system from pigeon liver at a rate comparable to that observed when acetate is used as a precursor. The first enzymic step for citrate incorporation is probably its breakdown to acetyl-CoA and oxaloacetate catalyzed by the citrate-cleavage enzyme. Experiments with variously labeled citrate show good incorporation of the acetyl portion of citrate into fatty acids, and a poor incorporation of the oxaloacetyl portion into fatty acids. The incorporation of the oxaloacetyl portion of citrate as well as the acetyl portion has been shown to be avidin sensitive. The enzymic sequence from the oxaloacetyl portion remains uncertain.

Original languageEnglish
Pages (from-to)221-230
Number of pages10
JournalBBA - Specialised Section On Lipids and Related Subjects
Volume70
Issue numberC
Publication statusPublished - 1963

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Citric Acid
Fatty Acids
Carbon
ATP Citrate (pro-S)-Lyase
Oxaloacetic Acid
Acetyl Coenzyme A
Avidin
Columbidae
Acetates
Liver
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The incorporation of citrate carbon into fatty acids. / Bhaduri, Amar; Srere, P.

In: BBA - Specialised Section On Lipids and Related Subjects, Vol. 70, No. C, 1963, p. 221-230.

Research output: Contribution to journalArticle

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