A mikronizálás jelentosége a gyó gyszerformák tervezésében I. Elméleti és biofarmáciai vonatkozások

Translated title of the contribution: The importance of micronization in the design of dosage forms I. Theoretical and biopharmaceutical aspects

Research output: Contribution to journalArticle

Abstract

The role of micronization is growing considering the optimization of the physicochemical characteristics of drug, dissolution enhancement and ensuring appropiate bioavailability. The importance of micronization can be understood on the basis of Noyes-Whitney equation, where the particle characteristics influence the active surface contacting with the dissolution medium, theoretically the solubility, and the boundary layer around the particle under certain hidrodynamic conditions. To adjudge the possibilities and limits of micronization concerning the dosage form design and preparations based on innovative pharmaceutical technology, it is necessary to take the detailed theoretical, physiological and biopharmaceutical aspects into consideration.

Original languageHungarian
Pages (from-to)95-103
Number of pages9
JournalActa Pharmaceutica Hungarica
Volume76
Issue number2
Publication statusPublished - 2006

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Pharmaceutical Technology
Dosage Forms
Solubility
Biological Availability
Drug Liberation

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

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title = "A mikroniz{\'a}l{\'a}s jelentos{\'e}ge a gy{\'o} gyszerform{\'a}k tervez{\'e}s{\'e}ben I. Elm{\'e}leti {\'e}s biofarm{\'a}ciai vonatkoz{\'a}sok",
abstract = "The role of micronization is growing considering the optimization of the physicochemical characteristics of drug, dissolution enhancement and ensuring appropiate bioavailability. The importance of micronization can be understood on the basis of Noyes-Whitney equation, where the particle characteristics influence the active surface contacting with the dissolution medium, theoretically the solubility, and the boundary layer around the particle under certain hidrodynamic conditions. To adjudge the possibilities and limits of micronization concerning the dosage form design and preparations based on innovative pharmaceutical technology, it is necessary to take the detailed theoretical, physiological and biopharmaceutical aspects into consideration.",
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