The involvement of immunological mechanisms is recognized in the background of habitual (recurrent) abortions although the major immunologic factor has not been determined yet. The changes and possible causal roles of the complex TLX/CD46/MCP antigen system and the cytotoxic T lymphocyte precursor frequency (CTLpf) are extensively investigated by international research groups. Our research group was among the first which also made extensive examinations in this disease group and our results were comparable to those published in the literature reporting that the CTLpf in recurrent spontaneous abortions (RSA) was significantly higher (p<0,001 ) than the values measured in healthy, fertile, non pregnant women. The partner specific CTL precursor frequency was found to be approximately ten times higher then the values in the relevant control group. The level of Fcγ receptor blocking antibodies which bind to the TLX/CD46/MCP antigen system was significantly lower in the sera of women with spontaneous abortions. These results confirm that the assessment of the anti-paternal cytotoxic T lymphocyte precursor frequencies and the levels of anti-TLX Fcγ receptor blocking antibodies seems to be a reliable test in the diagnostics of the immunological background of habitual abortions of unknown origin, in the selection of patients for effective immunotherapy and in their therapeutic follow-up. These examinations also serve as firm bases for the reality of correct domestic treatment of habitual abortions with immunological background.
|Number of pages||7|
|Publication status||Published - Dec 1 2002|
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