The impact of 99mTc-DTPA orbital SPECT in patient selection for external radiation therapy in Graves' ophthalmopathy

Lajos Szabados, E. Nagy, Bernadett Ujhelyi, Hilda Urbancsek, J. Varga, Edit Nagy, L. Galuska

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: In Graves' ophthalmopathy (GO), there is a demand to differentiate the immunologically active disease state, when immunosuppressive therapy is necessary, from the inactive state, when the patient would not benefit from it. We measured the inflammatory activity in the retrobulbar region using Tc-diethylene triamine pentaacetic acid (DTPA) SPECT before and after external radiation to determine whether this method is suitable for predicting the effectiveness of this therapy. MATERIALS AND METHODS: Thirty-two patients with suspected active GO were involved in this retrospective study. The initial image, DTPA uptake value (UV) and its change after therapy were assessed to monitor the effect of the therapy and investigate whether a pretreatment scan is capable of predicting the outcome. RESULTS: Depending on the change in DTPA UV after radiotherapy, three patient groups were formed: decreased, increased or minimally changed (less than 1×10-6 injected dose (ID)/ml). The initial DTPA UVs of these groups were significantly different (P-6 ID/ml) versus high (≥12×10-6 ID/ml) initial uptake, an unexpected increase was observed in the first group after therapy (mean: +2.89±2.66×10 -6 ID/ml), whereas the average change in the DTPA UV was negative in the latter group as anticipated (-2.24±4.47×10-6 ID/ml, P

Original languageEnglish
Pages (from-to)108-112
Number of pages5
JournalNuclear Medicine Communications
Volume34
Issue number2
DOIs
Publication statusPublished - Feb 2013

Fingerprint

Graves Ophthalmopathy
Single-Photon Emission-Computed Tomography
Patient Selection
Radiotherapy
Acids
Therapeutics
Immunosuppressive Agents
Group Psychotherapy
Retrospective Studies
diethylenetriamine
Radiation

Keywords

  • Tc-DTPA
  • Graves' ophthalmopathy
  • orbital radiation therapy
  • orbital SPECT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

The impact of 99mTc-DTPA orbital SPECT in patient selection for external radiation therapy in Graves' ophthalmopathy. / Szabados, Lajos; Nagy, E.; Ujhelyi, Bernadett; Urbancsek, Hilda; Varga, J.; Nagy, Edit; Galuska, L.

In: Nuclear Medicine Communications, Vol. 34, No. 2, 02.2013, p. 108-112.

Research output: Contribution to journalArticle

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