The impact of periventricular white matter lesions in patients with bipolar disorder type I

Gianluca Serafini, Maurizio Pompili, Marco Innamorati, Nicoletta Girardi, Leonardo Strusi, Mario Amore, Leo Sher, X. Gonda, Z. Ríhmer, Paolo Girardi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction White matter hyperintensities (WMHs) are one the most common neuroimaging findings in patients with bipolar disorder (BD). It has been suggested that WMHs are associated with impaired insight in schizophrenia and schizoaffective patients; however, the relationship between insight and WMHs in BD type I has not been directly investigated. Methods Patients with BD-I (148) were recruited and underwent brain magnetic resonance imaging (MRI). Affective symptoms were assessed using Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HDRS17); the presence of impaired insight was based on the corresponding items of YMRS and HDRS17. Results Multiple punctate periventricular WMHs (PWMHs) and deep WMHs (DWMHs) were observed in 49.3% and 39.9% of the cases, respectively. Subjects with lower insight for mania had significantly more PWMHs (54.6% vs 22.2%; p <0.05) when compared to BD-I patients with higher insight for mania. The presence of PWMHs was independently associated with lower insight for mania: patients who denied illness according to the YMRS were 4 times more likely to have PWMHs (95% CI: 1.21/13.42) than other patients. Conclusions Impaired insight in BD-I is associated with periventricular WMHs. The early identification of BD-I subjects with PWMHs and impaired insight may be crucial for clinicians.

Original languageEnglish
Pages (from-to)23-34
Number of pages12
JournalCNS Spectrums
Volume21
Issue number1
DOIs
Publication statusPublished - Jun 12 2013

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Bipolar Disorder
White Matter
Affective Symptoms
Neuroimaging
Schizophrenia
Magnetic Resonance Imaging
Depression

Keywords

  • Affective symptoms
  • BD-I
  • insight
  • MRI
  • periventricular WMHs

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Serafini, G., Pompili, M., Innamorati, M., Girardi, N., Strusi, L., Amore, M., ... Girardi, P. (2013). The impact of periventricular white matter lesions in patients with bipolar disorder type I. CNS Spectrums, 21(1), 23-34. https://doi.org/10.1017/S1092852913000825

The impact of periventricular white matter lesions in patients with bipolar disorder type I. / Serafini, Gianluca; Pompili, Maurizio; Innamorati, Marco; Girardi, Nicoletta; Strusi, Leonardo; Amore, Mario; Sher, Leo; Gonda, X.; Ríhmer, Z.; Girardi, Paolo.

In: CNS Spectrums, Vol. 21, No. 1, 12.06.2013, p. 23-34.

Research output: Contribution to journalArticle

Serafini, G, Pompili, M, Innamorati, M, Girardi, N, Strusi, L, Amore, M, Sher, L, Gonda, X, Ríhmer, Z & Girardi, P 2013, 'The impact of periventricular white matter lesions in patients with bipolar disorder type I', CNS Spectrums, vol. 21, no. 1, pp. 23-34. https://doi.org/10.1017/S1092852913000825
Serafini G, Pompili M, Innamorati M, Girardi N, Strusi L, Amore M et al. The impact of periventricular white matter lesions in patients with bipolar disorder type I. CNS Spectrums. 2013 Jun 12;21(1):23-34. https://doi.org/10.1017/S1092852913000825
Serafini, Gianluca ; Pompili, Maurizio ; Innamorati, Marco ; Girardi, Nicoletta ; Strusi, Leonardo ; Amore, Mario ; Sher, Leo ; Gonda, X. ; Ríhmer, Z. ; Girardi, Paolo. / The impact of periventricular white matter lesions in patients with bipolar disorder type I. In: CNS Spectrums. 2013 ; Vol. 21, No. 1. pp. 23-34.
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abstract = "Introduction White matter hyperintensities (WMHs) are one the most common neuroimaging findings in patients with bipolar disorder (BD). It has been suggested that WMHs are associated with impaired insight in schizophrenia and schizoaffective patients; however, the relationship between insight and WMHs in BD type I has not been directly investigated. Methods Patients with BD-I (148) were recruited and underwent brain magnetic resonance imaging (MRI). Affective symptoms were assessed using Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HDRS17); the presence of impaired insight was based on the corresponding items of YMRS and HDRS17. Results Multiple punctate periventricular WMHs (PWMHs) and deep WMHs (DWMHs) were observed in 49.3{\%} and 39.9{\%} of the cases, respectively. Subjects with lower insight for mania had significantly more PWMHs (54.6{\%} vs 22.2{\%}; p <0.05) when compared to BD-I patients with higher insight for mania. The presence of PWMHs was independently associated with lower insight for mania: patients who denied illness according to the YMRS were 4 times more likely to have PWMHs (95{\%} CI: 1.21/13.42) than other patients. Conclusions Impaired insight in BD-I is associated with periventricular WMHs. The early identification of BD-I subjects with PWMHs and impaired insight may be crucial for clinicians.",
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N2 - Introduction White matter hyperintensities (WMHs) are one the most common neuroimaging findings in patients with bipolar disorder (BD). It has been suggested that WMHs are associated with impaired insight in schizophrenia and schizoaffective patients; however, the relationship between insight and WMHs in BD type I has not been directly investigated. Methods Patients with BD-I (148) were recruited and underwent brain magnetic resonance imaging (MRI). Affective symptoms were assessed using Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HDRS17); the presence of impaired insight was based on the corresponding items of YMRS and HDRS17. Results Multiple punctate periventricular WMHs (PWMHs) and deep WMHs (DWMHs) were observed in 49.3% and 39.9% of the cases, respectively. Subjects with lower insight for mania had significantly more PWMHs (54.6% vs 22.2%; p <0.05) when compared to BD-I patients with higher insight for mania. The presence of PWMHs was independently associated with lower insight for mania: patients who denied illness according to the YMRS were 4 times more likely to have PWMHs (95% CI: 1.21/13.42) than other patients. Conclusions Impaired insight in BD-I is associated with periventricular WMHs. The early identification of BD-I subjects with PWMHs and impaired insight may be crucial for clinicians.

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