The Impact of Osteocalcin, Osteoprotegerin and Osteopontin on Arterial Stiffness in Chronic Renal Failure Patients on Hemodialysis

Botond Csiky, Balázs Sági, Attila Peti, Orsolya Lakatos, Viktória Prémusz, Endre Sulyok

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background/Aims: This cross-sectional study was designed to assess the relationship between vascular stiffness (VS) and bone-related proteins involved in the development of arteriosclerosis in patients on regular hemodialysis (HD). Methods: 68 consecutive patients in stable clinical condition who received regular HD in the FMC Dialysis Center, Pécs were included. VS parameters (carotid-femoral pulse wave velocity – PWV, aortic augmentation index - AIx) were determined by applanation tonometry (SphygmoCor, AtCor Medical, Sidney) and the routine latoratory test were completed with measurements of osteocalcin (OC), osteopontin (OP) and osteoprotegerin (OPG) by using commercially available ELISA kits. 35 heathcare workers served as controls. Results: In patients on regular HD PWV markedly increased and there was several-fold elevation in the interrelated bone-specific proteins (OC, OP, OPG). PWV was found to be independently associated only with OC (β:-0.25, p<0.029) and age (r=0.411,p<0.000), but risk factors for arterial calcification had significant impact on OC (systolic blood pressure, hsCRP, BMI), OPG (age, BMI) and OP (LDL-cholesterol). Conclusion: Except for OC, our results failed to document direct association of vascular lesion with OP and OPG, therefore their high circulating levels may be an epiphenomenon or they may have counter-regulatory role to attenuate the uremic calcification process.

Original languageEnglish
Pages (from-to)1312-1321
Number of pages10
JournalKidney and Blood Pressure Research
DOIs
Publication statusAccepted/In press - Dec 15 2017

Fingerprint

Osteoprotegerin
Vascular Stiffness
Osteopontin
Osteocalcin
Chronic Kidney Failure
Renal Dialysis
Blood Pressure
Bone and Bones
Pulse Wave Analysis
Arteriosclerosis
Manometry
Thigh
LDL Cholesterol
Blood Vessels
Dialysis
Proteins
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay

Keywords

  • Hemodialysis
  • Osteocalcin
  • Osteopontin
  • Osteoprotegerin
  • Pulse wave velocity
  • Vascular stiffness

ASJC Scopus subject areas

  • Nephrology
  • Cardiology and Cardiovascular Medicine

Cite this

The Impact of Osteocalcin, Osteoprotegerin and Osteopontin on Arterial Stiffness in Chronic Renal Failure Patients on Hemodialysis. / Csiky, Botond; Sági, Balázs; Peti, Attila; Lakatos, Orsolya; Prémusz, Viktória; Sulyok, Endre.

In: Kidney and Blood Pressure Research, 15.12.2017, p. 1312-1321.

Research output: Contribution to journalArticle

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