The impact of deterministic signal loss on oct angiography measurements

Cecilia Czakó, Lilla István, Fruzsina Benyó, Ágnes Élő, Gábor Erdei, Hajnalka Horváth, Zoltán Zsolt Nagy, Illés Kovács

Research output: Contribution to journalArticle


Purpose: In this study, we aimed at investigating the impact of deterministic signal loss on image quality and, thus, on optical coherence tomography angiography (OCTA) measurements performed by the RTVue-XR Avanti System. Methods: Absorptive filters with different optical densities (ODs) were used to simulate signal loss in a controlled way in 30 eyes from 15 healthy subjects. Scan Quality (SQ), provided by the AngioVue software, was applied as a measure of image quality. Results: Assessing the effect of decreased light transmittance on SQ values as well as that of attenuated image quality on OCTA parameters revealed a strong systematic dependence between these quantities. Attenuated image quality was associated with significantly decreased macular and peripapillary vessel density (VD) values, and we calculated a correction factor of 2.27% to 3.97% for a one-unit change in SQ for the different VD parameters. Conclusions: Our findings suggest that the influence of systematic changes in image quality on OCTA parameters needs to be considered during patient follow-up in order to make valid assessment of progression. Translational Relevance: For accurate evaluation of longitudinal changes in OCTA parameters, equal scan quality or using a correction factor is suggested.

Original languageEnglish
Article number10
JournalTranslational Vision Science and Technology
Issue number5
Publication statusPublished - Apr 2020


  • Image quality
  • OCT angiography
  • Retinal vessel density

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology

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  • Cite this

    Czakó, C., István, L., Benyó, F., Élő, Á., Erdei, G., Horváth, H., Nagy, Z. Z., & Kovács, I. (2020). The impact of deterministic signal loss on oct angiography measurements. Translational Vision Science and Technology, 9(5), [10].