A jelenlegi ajánlások szerinti antihipertenzív terápia hatása a depresszióra és egyéb pszichometriai paraméterekre: Előzetes eredmények

Translated title of the contribution: The impact of currently recommended antihypertensive therapy on depression and other psychometric parameters: Preliminary communication

Beata Korosi, Andrea Laszlo, A. Tabák, Dora Batta, Lilla Lenart, Andrea Fekete, Daniel Eorsi, Orsolya Cseprekal, A. Tislér, Zsofia Nemcsik-Bencze, X. Gonda, Z. Ríhmer, János Nemcsik

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aims: Current evidence on the psychological effects of antihypertensive medications is controversial. The aim of this study was to evaluate the effect of current antihypertensive medication on different psychometric parameters and on serum brain-derived neurotrophic factor (BDNF) level. Methods: Psychometric, haemodynamic, arterial stiffness and laboratory parameters were evaluated before and 3 months after the initiation of antihypertensive medication in untreated hypertensive patients (HT, n=31), and once in healthy controls (CONT, n=22). Subjects completed the following psychometric tests: Beck Depression Inventory (BDI), Hamilton Anxiety Scale (HAM-A), Symptom Checklist 90 Revised (SCL-90), Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire, Big Five Inventory, Pain Vigilance and Awareness Questionnaire and Berkeley Expressivity Questionnaire. Amlodipine and/or perindopril compounds were preferred medications. Serum BDNF was measured with ELISA. Results: Brachial systolic blood pressure, as well as pulse wave velocity were significantly improved in the HT group over the 3-month follow-up (153.3±15.9 mmHg vs. 129.5±10.0 mmHg and 8.2±1.4 m/s vs 7.5±1.6 m/s, respectively). Similarly, we found improvements in BDI (0.73 points) and in several Scl-90 subscales. Serum BDNF was not different between CONT and HT and did not change for therapy. Conclusions: Our results indicate that initiation of currently recommended antihypertensive medications in newly diagnosed patients may have a significant impact on psychological well-being of patients and could influence quality of life as well.

Original languageHungarian
Pages (from-to)11-22
Number of pages12
JournalNeuropsychopharmacologia Hungarica
Volume19
Issue number1
Publication statusPublished - Jan 1 2017

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Psychometrics
Antihypertensive Agents
Brain-Derived Neurotrophic Factor
Communication
Depression
Equipment and Supplies
Serum
Psychology
Blood Pressure
Pulse Wave Analysis
Vascular Stiffness
Temperament
Paris
Therapeutics
Checklist
Arm
Anxiety
Hemodynamics
Enzyme-Linked Immunosorbent Assay
Quality of Life

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Clinical Neurology

Cite this

A jelenlegi ajánlások szerinti antihipertenzív terápia hatása a depresszióra és egyéb pszichometriai paraméterekre : Előzetes eredmények. / Korosi, Beata; Laszlo, Andrea; Tabák, A.; Batta, Dora; Lenart, Lilla; Fekete, Andrea; Eorsi, Daniel; Cseprekal, Orsolya; Tislér, A.; Nemcsik-Bencze, Zsofia; Gonda, X.; Ríhmer, Z.; Nemcsik, János.

In: Neuropsychopharmacologia Hungarica, Vol. 19, No. 1, 01.01.2017, p. 11-22.

Research output: Contribution to journalArticle

Korosi, Beata ; Laszlo, Andrea ; Tabák, A. ; Batta, Dora ; Lenart, Lilla ; Fekete, Andrea ; Eorsi, Daniel ; Cseprekal, Orsolya ; Tislér, A. ; Nemcsik-Bencze, Zsofia ; Gonda, X. ; Ríhmer, Z. ; Nemcsik, János. / A jelenlegi ajánlások szerinti antihipertenzív terápia hatása a depresszióra és egyéb pszichometriai paraméterekre : Előzetes eredmények. In: Neuropsychopharmacologia Hungarica. 2017 ; Vol. 19, No. 1. pp. 11-22.
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AU - Korosi, Beata

AU - Laszlo, Andrea

AU - Tabák, A.

AU - Batta, Dora

AU - Lenart, Lilla

AU - Fekete, Andrea

AU - Eorsi, Daniel

AU - Cseprekal, Orsolya

AU - Tislér, A.

AU - Nemcsik-Bencze, Zsofia

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