The immunomodulatory effect of human IgG Fc fragments on the oxazolone-specific immune response of high and low responder mice

J. Kulics, E. Rajnavolgyi, G. László, J. Gergely

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Intravenous injection of human IgG Fc fragments in mice resulted in the stimulation or inhibition of an oxazolone-specific antibody response depending on the schedule of Fc fragment injection. High and low responder mice for oxazolone were injected with Fc fragments according to two protocols: either on the day of oxazolone priming, or together with the oxazolone boost, and the isotype composition of oxazolone-specific antibodies was analysed by solid phase radioimmunoassay. We found the primary and secondary anti-oxazolone IgM levels increased in all instances, irrespective of the schedule of Fc fragment treatment. In contrast, the oxazolone-specific IgG production was increased only if Fc fragments were injected at the time of antigen priming. Injection of Fc fragments together with a secondary injection of oxazolone resulted in the inhibition of oxazolone-specific IgG production. Both stimulation and inhibition of oxazolone-specific antibodies were more pronounced in the low responder C57BL/6 mice strain.

Original languageEnglish
Pages (from-to)321-327
Number of pages7
JournalImmunology Letters
Volume12
Issue number5-6
DOIs
Publication statusPublished - 1986

Fingerprint

Oxazolone
Immunoglobulin Fc Fragments
Immunoglobulin G
Injections
Appointments and Schedules
Antibodies
Inbred C57BL Mouse
Intravenous Injections
Antibody Formation
Radioimmunoassay

Keywords

  • IgG Fc fragment
  • immunomodulation
  • isotype distribution
  • oxazolone response

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The immunomodulatory effect of human IgG Fc fragments on the oxazolone-specific immune response of high and low responder mice. / Kulics, J.; Rajnavolgyi, E.; László, G.; Gergely, J.

In: Immunology Letters, Vol. 12, No. 5-6, 1986, p. 321-327.

Research output: Contribution to journalArticle

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AU - Gergely, J.

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