A hidrogén-peroxid paradoxon

Translated title of the contribution: The hydrogen peroxide paradox

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Since the discovery of hydrogen peroxide in 1819 it was known as a toxic agent for human organs. Due to the recent findings its role should be reevaluated. This review discusses the toxic and physiological roles of hydrogen peroxide and functions of enzyme catalase which is the main regulator of hydrogen peroxide metabolism. The concentration of hydrogen peroxide changes between 0,05 μmol/l and 117 μmol/l in expaired breath condensate and in human fluids. Hydrogen peroxide is generated by physiological processes such as glycation, phagocytosis, cell metabolism and by pathological changes such as different tumors and side effects of some drugs. The main regulator of toxic concentration of hydrogen peroxide is the enzyme catalase while the glutathione peroxidase and hemoglobin has a limited role in this process. The low concentration of hydroge peroxide plays a role in degradation of some proteins, as a messenger in cell signaling and could contribute to the apoptosis. Enzyme catalase due to its structure and function is very effective in destroying the toxic concentration of hydrogen peroxide without changing its low, physiological concentration. The decrease in catalase due to anemia, decreased synthesis and especially to its inherited deficiency may be a risk factor in diabetes, cell damage due to ischemia, in uricase and ascorbic acid treatment as well as in sterilization with hydrogen peroxide. The hydrogen peroxide paradox means that its low concentration is vital for some physiological processes while its high concentration is toxic for human cells. The main regulator of hydrogen peroxide concentration is the enzyme catalase and its deficiency may be a risk factor for some pathological changes.

Original languageHungarian
Pages (from-to)887-893
Number of pages7
JournalOrvosi Hetilap
Volume147
Issue number19
Publication statusPublished - May 14 2006

Fingerprint

Hydrogen Peroxide
Poisons
Catalase
Physiological Phenomena
Enzymes
Acatalasia
Urate Oxidase
Cytophagocytosis
Peroxides
Glutathione Peroxidase
Drug-Related Side Effects and Adverse Reactions
Proteolysis
Ascorbic Acid
Anemia
Hemoglobins
Ischemia
Apoptosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A hidrogén-peroxid paradoxon. / Góth, L.

In: Orvosi Hetilap, Vol. 147, No. 19, 14.05.2006, p. 887-893.

Research output: Contribution to journalArticle

Góth, L 2006, 'A hidrogén-peroxid paradoxon', Orvosi Hetilap, vol. 147, no. 19, pp. 887-893.
Góth L. A hidrogén-peroxid paradoxon. Orvosi Hetilap. 2006 May 14;147(19):887-893.
Góth, L. / A hidrogén-peroxid paradoxon. In: Orvosi Hetilap. 2006 ; Vol. 147, No. 19. pp. 887-893.
@article{019d0e333d5d44a9b20486589a4e77da,
title = "A hidrog{\'e}n-peroxid paradoxon",
abstract = "Since the discovery of hydrogen peroxide in 1819 it was known as a toxic agent for human organs. Due to the recent findings its role should be reevaluated. This review discusses the toxic and physiological roles of hydrogen peroxide and functions of enzyme catalase which is the main regulator of hydrogen peroxide metabolism. The concentration of hydrogen peroxide changes between 0,05 μmol/l and 117 μmol/l in expaired breath condensate and in human fluids. Hydrogen peroxide is generated by physiological processes such as glycation, phagocytosis, cell metabolism and by pathological changes such as different tumors and side effects of some drugs. The main regulator of toxic concentration of hydrogen peroxide is the enzyme catalase while the glutathione peroxidase and hemoglobin has a limited role in this process. The low concentration of hydroge peroxide plays a role in degradation of some proteins, as a messenger in cell signaling and could contribute to the apoptosis. Enzyme catalase due to its structure and function is very effective in destroying the toxic concentration of hydrogen peroxide without changing its low, physiological concentration. The decrease in catalase due to anemia, decreased synthesis and especially to its inherited deficiency may be a risk factor in diabetes, cell damage due to ischemia, in uricase and ascorbic acid treatment as well as in sterilization with hydrogen peroxide. The hydrogen peroxide paradox means that its low concentration is vital for some physiological processes while its high concentration is toxic for human cells. The main regulator of hydrogen peroxide concentration is the enzyme catalase and its deficiency may be a risk factor for some pathological changes.",
keywords = "Acatalasemia, Catalase, Hydrogen peroxide, Physiological role, Risk factors, Toxic role",
author = "L. G{\'o}th",
year = "2006",
month = "5",
day = "14",
language = "Hungarian",
volume = "147",
pages = "887--893",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "19",

}

TY - JOUR

T1 - A hidrogén-peroxid paradoxon

AU - Góth, L.

PY - 2006/5/14

Y1 - 2006/5/14

N2 - Since the discovery of hydrogen peroxide in 1819 it was known as a toxic agent for human organs. Due to the recent findings its role should be reevaluated. This review discusses the toxic and physiological roles of hydrogen peroxide and functions of enzyme catalase which is the main regulator of hydrogen peroxide metabolism. The concentration of hydrogen peroxide changes between 0,05 μmol/l and 117 μmol/l in expaired breath condensate and in human fluids. Hydrogen peroxide is generated by physiological processes such as glycation, phagocytosis, cell metabolism and by pathological changes such as different tumors and side effects of some drugs. The main regulator of toxic concentration of hydrogen peroxide is the enzyme catalase while the glutathione peroxidase and hemoglobin has a limited role in this process. The low concentration of hydroge peroxide plays a role in degradation of some proteins, as a messenger in cell signaling and could contribute to the apoptosis. Enzyme catalase due to its structure and function is very effective in destroying the toxic concentration of hydrogen peroxide without changing its low, physiological concentration. The decrease in catalase due to anemia, decreased synthesis and especially to its inherited deficiency may be a risk factor in diabetes, cell damage due to ischemia, in uricase and ascorbic acid treatment as well as in sterilization with hydrogen peroxide. The hydrogen peroxide paradox means that its low concentration is vital for some physiological processes while its high concentration is toxic for human cells. The main regulator of hydrogen peroxide concentration is the enzyme catalase and its deficiency may be a risk factor for some pathological changes.

AB - Since the discovery of hydrogen peroxide in 1819 it was known as a toxic agent for human organs. Due to the recent findings its role should be reevaluated. This review discusses the toxic and physiological roles of hydrogen peroxide and functions of enzyme catalase which is the main regulator of hydrogen peroxide metabolism. The concentration of hydrogen peroxide changes between 0,05 μmol/l and 117 μmol/l in expaired breath condensate and in human fluids. Hydrogen peroxide is generated by physiological processes such as glycation, phagocytosis, cell metabolism and by pathological changes such as different tumors and side effects of some drugs. The main regulator of toxic concentration of hydrogen peroxide is the enzyme catalase while the glutathione peroxidase and hemoglobin has a limited role in this process. The low concentration of hydroge peroxide plays a role in degradation of some proteins, as a messenger in cell signaling and could contribute to the apoptosis. Enzyme catalase due to its structure and function is very effective in destroying the toxic concentration of hydrogen peroxide without changing its low, physiological concentration. The decrease in catalase due to anemia, decreased synthesis and especially to its inherited deficiency may be a risk factor in diabetes, cell damage due to ischemia, in uricase and ascorbic acid treatment as well as in sterilization with hydrogen peroxide. The hydrogen peroxide paradox means that its low concentration is vital for some physiological processes while its high concentration is toxic for human cells. The main regulator of hydrogen peroxide concentration is the enzyme catalase and its deficiency may be a risk factor for some pathological changes.

KW - Acatalasemia

KW - Catalase

KW - Hydrogen peroxide

KW - Physiological role

KW - Risk factors

KW - Toxic role

UR - http://www.scopus.com/inward/record.url?scp=33746089222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746089222&partnerID=8YFLogxK

M3 - Article

C2 - 16784144

AN - SCOPUS:33746089222

VL - 147

SP - 887

EP - 893

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 19

ER -