The human superior cervical ganglion: Neuropeptides and peptide receptors

Janos Tajti, Sebastian Möller, Rolf Uddman, Istvan Bodi, Lars Edvinsson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Noradrenaline (NA)- and neuropeptide Y (NPY)- containing cell bodies were found to occur in high numbers (>75% of all cells were positive) in the human superior cervical ganglion and distributed homogeneously throughout the ganglion and showed colocalisation. A few cell bodies were VIP-immunoreactive (-ir) (less than 5%) but none of them showed NOS-, CGRP- or SP-ir. Receptor mRNA expression was studied with RT-PCR. Total RNA from the superior cervical ganglion was successfully extracted. By using appropriate sense and antisense oligonucleotides designed from the published human sequences, we could show the presence of mRNA for the human NPY Y1 NPY Y2 and VPAC1 receptors but not CGRP1 receptor mRNA.

Original languageEnglish
Pages (from-to)121-124
Number of pages4
JournalNeuroscience Letters
Volume263
Issue number2-3
DOIs
Publication statusPublished - Mar 26 1999

Keywords

  • CGRP
  • Human superior cervical ganglion
  • Immunocytochemistry
  • NPY Y2 receptor mRNA
  • Neuropeptides
  • Reverse transcriptase polymerase chain reaction
  • VPAC NPY Y

ASJC Scopus subject areas

  • Neuroscience(all)

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