The hippocampus plays a role in the recognition of visual scenes presented at behaviorally relevant points in time: Evidence from amnestic mild cognitive impairment (aMCI) and healthy controls

András Szamosi, Einat Levy-Gigi, O. Kelemen, S. Kéri

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

When people perform an attentionally demanding target task at fixation, they also encode the surrounding visual environment, which serves as a context of the task. Here, we examined the role of the hippocampus in memory for target and context. Thirty-five patients with amnestic mild cognitive impairment (aMCI) and 35 healthy controls matched for age, gender, and education participated in the study. Participants completed visual letter detection and auditory tone discrimination target tasks, while also viewing a series of briefly presented urban and natural scenes. For the measurement of hippocampal and cerebral cortical volume, we utilized the FreeSurfer protocol using a Siemens Trio 3T scanner. Before the quantification of brain volumes, hippocampal atrophy was confirmed by visual inspection in each patient. Results revealed intact letter recall and tone discrimination performances in aMCI patients, whereas they showed severe impairments in the recognition of scenes presented together with the targets. Patients with aMCI showed bilaterally reduced hippocampal volumes, but intact cortical volume, as compared with the controls. In controls and in the whole sample, hippocampal volume was positively associated with scene recognition when a target task was present. This relationship was observed in both visual and auditory conditions. Scene recognition and target tasks were not associated with executive functions. These results suggest that the hippocampus plays an essential role in the formation of memory traces of the visual environment when people concurrently perform a target task at behaviorally relevant points in time.

Original languageEnglish
Pages (from-to)1892-1900
Number of pages9
JournalCortex
Volume49
Issue number7
DOIs
Publication statusPublished - Jul 2013

Fingerprint

Hippocampus
Executive Function
Atrophy
Education
Cognitive Dysfunction
Recognition (Psychology)
Mild Cognitive Impairment
Brain
Discrimination (Psychology)

Keywords

  • Amnestic mild cognitive impairment
  • Hippocampus
  • Memory
  • Rapid serial visual presentation
  • Visual scene

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

Cite this

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abstract = "When people perform an attentionally demanding target task at fixation, they also encode the surrounding visual environment, which serves as a context of the task. Here, we examined the role of the hippocampus in memory for target and context. Thirty-five patients with amnestic mild cognitive impairment (aMCI) and 35 healthy controls matched for age, gender, and education participated in the study. Participants completed visual letter detection and auditory tone discrimination target tasks, while also viewing a series of briefly presented urban and natural scenes. For the measurement of hippocampal and cerebral cortical volume, we utilized the FreeSurfer protocol using a Siemens Trio 3T scanner. Before the quantification of brain volumes, hippocampal atrophy was confirmed by visual inspection in each patient. Results revealed intact letter recall and tone discrimination performances in aMCI patients, whereas they showed severe impairments in the recognition of scenes presented together with the targets. Patients with aMCI showed bilaterally reduced hippocampal volumes, but intact cortical volume, as compared with the controls. In controls and in the whole sample, hippocampal volume was positively associated with scene recognition when a target task was present. This relationship was observed in both visual and auditory conditions. Scene recognition and target tasks were not associated with executive functions. These results suggest that the hippocampus plays an essential role in the formation of memory traces of the visual environment when people concurrently perform a target task at behaviorally relevant points in time.",
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