Hepatitis C vírus--a non-A, non-B hepatitis fö kórokozója.

Translated title of the contribution: The hepatitis C virus--principal causative agent in non-A, non-B hepatitis

Research output: Contribution to journalArticle

Abstract

The diagnosis of non-A, non-B (NANB) hepatitis was based on the exclusion of hepatitis A and B infection and other known causes of hepatitis, such as other viruses, alcohol and toxic effects. More recently, an RNA has been isolated from a NANB-infected chimpanzee serum and with its aid a polypeptide antigen was produced by molecular biological methods. Antibodies to this antigen--as part of the infectious agent, called hepatitis C virus (HCV)--were detected in the sera of infected patients. Studies with this antigen/antibody system proved, the HCV is responsible for the majority of posttransfusion and sporadic NANB hepatitis cases worldwide. The antibody appears late, in the serum up to 6 months after the infection. The occurrence of the infection is high among hemophiliacs and drug abusers. Anti-HCV antibody was detected also in certain liver disease with "unknown etiology" (chronic active hepatitis, primary biliary cirrhosis). This newly developed test provides the possibility to prove HCV infection in different groups of patients by detecting an antibody to a component of HCV.

Original languageHungarian
Pages (from-to)1903-1906
Number of pages4
JournalOrvosi Hetilap
Volume131
Issue number35
Publication statusPublished - Sep 2 1990

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Hepacivirus
Hepatitis
Antibodies
Antigens
Infection
Serum
Hepatitis C Antibodies
Pan troglodytes
Hepatitis A
Biliary Liver Cirrhosis
Poisons
Virus Diseases
Chronic Hepatitis
Drug Users
Hepatitis B
Liver Diseases
Alcohols
RNA
Viruses
Peptides

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hepatitis C vírus--a non-A, non-B hepatitis fö kórokozója. / Schaff, Z.; Lapis, K.

In: Orvosi Hetilap, Vol. 131, No. 35, 02.09.1990, p. 1903-1906.

Research output: Contribution to journalArticle

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