The heat shock connection of metabolic stress and dietary restriction

Balázs Dancsó, Zoltán Spiró, Mehmet Alper Arslan, Minh Tú Nguyen, Diána Papp, P. Csermely, C. Söti

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Molecular chaperones and the heat shock response guard and modulate protein conformation, protect proteins from misfolding and aggregation, and maintain signalling and organellar networks. Overnutrition and the metabolic syndrome represent a pro-aging condition, and dietary restriction is the most robust environmental intervention that induces longevity from yeast to mammals. In recent years a considerable effort has been made to elucidate the signaling pathways involved in metabolic signaling. Here we review the current understanding on the connection between metabolic stress, dietary restriction and the heat shock response and highlight results showing chaperone induction as a promising therapeutic strategy to promote healthy aging and to prevent metabolic disorders.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalCurrent Pharmaceutical Biotechnology
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Heat-Shock Response
Physiological Stress
Shock
Hot Temperature
Overnutrition
Protein Conformation
Molecular Chaperones
Mammals
Yeasts
Proteins
Therapeutics

Keywords

  • Aging
  • Caloric restriction
  • Diabetes
  • Heat shock response
  • Resveratrol
  • Sirtuin

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Biotechnology

Cite this

The heat shock connection of metabolic stress and dietary restriction. / Dancsó, Balázs; Spiró, Zoltán; Arslan, Mehmet Alper; Nguyen, Minh Tú; Papp, Diána; Csermely, P.; Söti, C.

In: Current Pharmaceutical Biotechnology, Vol. 11, No. 2, 02.2010, p. 139-145.

Research output: Contribution to journalArticle

Dancsó, Balázs ; Spiró, Zoltán ; Arslan, Mehmet Alper ; Nguyen, Minh Tú ; Papp, Diána ; Csermely, P. ; Söti, C. / The heat shock connection of metabolic stress and dietary restriction. In: Current Pharmaceutical Biotechnology. 2010 ; Vol. 11, No. 2. pp. 139-145.
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