The H-phosphonate approach to the synthesis of phosphopeptides on solid phase

Zoltán Kupihár, Zoltán Kele, Gábor K. Tóth

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

(matrix presented) Ammonium tert-butyl H-phosphonate was used for the phosphorylation of Tyr- and Ser-containing peptides synthesized by an Fmoc strategy. This reaction, leading to a monoprotected peptide phosphate, was found to be highly efficient and generally applicable. Moreover, the method employed avoids undesired side reactions during chain elongation (pyrophosphate formation and β-elimination catalyzed by piperidine).

Original languageEnglish
Pages (from-to)1033-1035
Number of pages3
JournalOrganic Letters
Volume3
Issue number7
DOIs
Publication statusPublished - Apr 5 2001

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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