A gyulladásos bélbetegségek genetikája

Translated title of the contribution: The genetics of inflammatory bowel disease

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The pathogenesis of inflammatory bowel disease is only partly understood; various environmental and host factors (e.g., genetic, epithelial, immune and non-immune) are involved. It is a multifactorial polygenic disease probably with genetic heterogeneity; some genes confer susceptibility to IBD in general, while others specifically increase the risk of ulcerative colitis or Crohn's disease or affect location (localized or extensive) and/or behaviour (e.g., mild, severe, aggressive). This review presents recent advances in the genetics of inflammatory bowel disease including chromosome segments newly recognized to be involved in inflammatory bowel disease as well as the role of NOD2/CARD15, SLC22A4/A5 and DLG5. The increasing genetic information provides, for the time being, a better understanding of the pathogenesis of the disease thus setting a basis for potential targets for therapeutic intervention. In the future, however, genetics may also help in refining the diagnosis or predicting disease course.

Translated title of the contributionThe genetics of inflammatory bowel disease
Original languageHungarian
Pages (from-to)121-129
Number of pages9
JournalLege Artis Medicinae
Volume16
Issue number2
Publication statusPublished - Feb 1 2006

ASJC Scopus subject areas

  • Medicine(all)

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