The genetics of antiplatelet drug resistance

Gergely Feher, A. Feher, G. Pusch, G. Lupkovics, L. Szapary, E. Papp

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

Platelets have a central role in the development of arterial thrombosis and subsequent cardiovascular events. An appreciation of this complex process has made antiplatelet therapy the cornerstone of cardiovascular disease management. However, numerous patients will experience a recurrent atherothrombotic vascular event despite adequate antiplatelet therapy. Individual differences in the rate of platelet activation and reactivity markedly influence normal hemostasis and the pathological outcome of thrombosis. Such an individual variability is largely determined by environmental and genetic factors. These are known to either hamper platelets' response to agonists, and thereby mimic the pharmacological modulation of platelet function or mask therapy effect and sensitize platelets. In this article, we reviewed the antiplatelet mechanisms of aspirin and clopidogrel and the possible role of different polymorphisms, which may affect the efficacy of antiplatelet therapy. Heterogeneity in the way patients respond to aspirin and clopidogrel may in part reflect variation in cyclooxygenase (COX)-1, COX-2, glycoprotein (GP) Ib alpha, GP Ia/IIa, GP IIb/IIIa, UGT1A6*2, P2Y1, P2Y12, CYP2C9, CYP3A4 and CYP3A5 genotypes.

Original languageEnglish
Pages (from-to)1-18
Number of pages18
JournalClinical Genetics
Volume75
Issue number1
DOIs
Publication statusPublished - Jan 9 2009

    Fingerprint

Keywords

  • Aspirin
  • Clopidogrel
  • Genetical polymorphism
  • Resistance
  • Variability

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this