The GABAA receptor channel mediated chloride ion translocation through the plasma membrane: New insights from 36Cl ion flux measurements

Research output: Contribution to journalReview article

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Abstract

GABAA receptors in plasma membranes of neurons are integral oligomers which form chloride channels. The binding of GABA molecules at recognition sites for channel opening triggers a transient increase in transmembrane chloride ion flux. The multiplicity and drug specificity of GABAA receptor, kinetics of channel opening, and desensitization of GABAA receptor and its short‐ and long‐term regulation have been investigated by the use of tracer amounts of the radioactive chloride isotope, 36Cl ion. Results and new insights from 36Cl ion flux measurements have been reviewed. © 1993 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)74-93
Number of pages20
JournalSynapse
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 1993

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Keywords

  • GABA response
  • Native oligomers
  • Radioactive chloride isotope

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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