The functions of polymorphonuclear leukocytes emigrating into the skin

M. Csato, A. Dobozy, L. Raith, N. Simon

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The functions of polymorphonuclear leukocytes (PMNs) emigrating into the skin and of others separated simultaneously from the circulation were determined and compared in healthy individuals. The PMNs emigrating into the skin were separated with a skin chamber technique. The C3 rosette forming capacities of the skin migrating and the circulating PMNs were similar. The chemotactic responsiveness was evaluated using three different chemoattractants: zymosan-activated serum, casein and lymphocyte-derived chemotactic factor. The skin PMNs gave practically no chemotactic response in the Boyden chamber, irrespective of the chemoattractant used. On the other hand, the skin PMNs exhibited higher plastic surface adherence, nitroblue tetrazolium reduction and Candida albicans killing activities. The data indicate that some functional activities of PMNs undergo alteration during in vivo emigration into the skin. The alterations, overall, may be of importance in the physiological protective function of the skin.

Original languageEnglish
Pages (from-to)106-110
Number of pages5
JournalActa Dermato-Venereologica
Volume65
Issue number2
Publication statusPublished - 1985

Fingerprint

Neutrophils
Skin
Chemotactic Factors
Nitroblue Tetrazolium
Zymosan
Emigration and Immigration
Caseins
Candida albicans
Plastics
Serum

ASJC Scopus subject areas

  • Dermatology

Cite this

The functions of polymorphonuclear leukocytes emigrating into the skin. / Csato, M.; Dobozy, A.; Raith, L.; Simon, N.

In: Acta Dermato-Venereologica, Vol. 65, No. 2, 1985, p. 106-110.

Research output: Contribution to journalArticle

Csato, M. ; Dobozy, A. ; Raith, L. ; Simon, N. / The functions of polymorphonuclear leukocytes emigrating into the skin. In: Acta Dermato-Venereologica. 1985 ; Vol. 65, No. 2. pp. 106-110.
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