The functions of polymorphonuclear leukocytes (PMN's) emigrating into the clinically uninvolved skin and of others separated simultaneously from the circulation were determined in patients suffering from widespread psoriasis. The C3 rosette forming capacity of the skin PMN's was lower when compared to that of the circulating PMN's. The skin PMN's gave practically no chemotactic response in the Boyden chamber, while the nitroblue tetrazolium reduction and the Candida albicans killing activities of the PMN's in the skin and in the circulation were similar. As a whole, the functions of the PMN's emigrating into the uninvolved skin of patients with widespread psoriasis did not differ from those of the skin PMN's separated from healthy individuals. These observations refer to the fact that although the PMN's exhibit some abnormalities in the circulation of patients with widespread psoriasis, the functions are completely normalized after the in vivo emigration into the unaffected skin.
|Number of pages||4|
|Publication status||Published - Jan 1 1985|
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