The frequency of Trp64Arg polymorphism of the β 3-adrenergic receptor gene in healthy and obese Hungarian children and its association with cardiovascular risk factors

E. Erhardt, M. Czakó, K. Csernus, D. Molnár, G. Kosztolányi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: To estimate the frequency of Arg64 allele of the β3-adrenergic receptor (3-BAR) gene in healthy (H) and obese (O) Hungarian children, and to look for possible associations between this polymorphism and some clinical and metabolic characteristics of obese children. Patients/methods: In all, 147 healthy (male: 68) and 295 obese (male: 168) children were examined. The average age of the children in the two groups was 12.4±1.7 vs 12.6±3.2, respectively. Exon 1 of 3-BAR was amplified by polymerase chain reaction and the fragments were digested with BstN1. In obese children, oral glucose tolerance test was carried out and blood pressure (BP) was checked. Results: The frequency of Trp64Arg polymorphism in normal and obese Hungarian children was similar (H vs O: n = 14/9.5% vs n = 35/11.8%). Obese children carrying the Arg64 allele (n = 35, male: 23) were compared to randomly chosen, obese children without the Arg64 allele (n = 35, male: 20). A significant difference was found between the body weight (81.2±23.2 vs 75.6±17.7kg; mean±s.d.; P

Original languageEnglish
Pages (from-to)955-959
Number of pages5
JournalEuropean Journal of Clinical Nutrition
Volume59
Issue number8
DOIs
Publication statusPublished - Aug 2005

Fingerprint

adrenergic receptors
Adrenergic Receptors
risk factors
genetic polymorphism
Genes
genes
Alleles
alleles
Glucose Tolerance Test
Gene Frequency
exons
blood pressure
gene frequency
Exons
polymerase chain reaction
Body Weight
Blood Pressure
Polymerase Chain Reaction
body weight

Keywords

  • β3-adrenergic receptor gene
  • Cardiovascular risk factors
  • Trp64Arg polymorphism

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

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title = "The frequency of Trp64Arg polymorphism of the β 3-adrenergic receptor gene in healthy and obese Hungarian children and its association with cardiovascular risk factors",
abstract = "Objective: To estimate the frequency of Arg64 allele of the β3-adrenergic receptor (3-BAR) gene in healthy (H) and obese (O) Hungarian children, and to look for possible associations between this polymorphism and some clinical and metabolic characteristics of obese children. Patients/methods: In all, 147 healthy (male: 68) and 295 obese (male: 168) children were examined. The average age of the children in the two groups was 12.4±1.7 vs 12.6±3.2, respectively. Exon 1 of 3-BAR was amplified by polymerase chain reaction and the fragments were digested with BstN1. In obese children, oral glucose tolerance test was carried out and blood pressure (BP) was checked. Results: The frequency of Trp64Arg polymorphism in normal and obese Hungarian children was similar (H vs O: n = 14/9.5{\%} vs n = 35/11.8{\%}). Obese children carrying the Arg64 allele (n = 35, male: 23) were compared to randomly chosen, obese children without the Arg64 allele (n = 35, male: 20). A significant difference was found between the body weight (81.2±23.2 vs 75.6±17.7kg; mean±s.d.; P",
keywords = "β3-adrenergic receptor gene, Cardiovascular risk factors, Trp64Arg polymorphism",
author = "E. Erhardt and M. Czak{\'o} and K. Csernus and D. Moln{\'a}r and G. Kosztol{\'a}nyi",
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T1 - The frequency of Trp64Arg polymorphism of the β 3-adrenergic receptor gene in healthy and obese Hungarian children and its association with cardiovascular risk factors

AU - Erhardt, E.

AU - Czakó, M.

AU - Csernus, K.

AU - Molnár, D.

AU - Kosztolányi, G.

PY - 2005/8

Y1 - 2005/8

N2 - Objective: To estimate the frequency of Arg64 allele of the β3-adrenergic receptor (3-BAR) gene in healthy (H) and obese (O) Hungarian children, and to look for possible associations between this polymorphism and some clinical and metabolic characteristics of obese children. Patients/methods: In all, 147 healthy (male: 68) and 295 obese (male: 168) children were examined. The average age of the children in the two groups was 12.4±1.7 vs 12.6±3.2, respectively. Exon 1 of 3-BAR was amplified by polymerase chain reaction and the fragments were digested with BstN1. In obese children, oral glucose tolerance test was carried out and blood pressure (BP) was checked. Results: The frequency of Trp64Arg polymorphism in normal and obese Hungarian children was similar (H vs O: n = 14/9.5% vs n = 35/11.8%). Obese children carrying the Arg64 allele (n = 35, male: 23) were compared to randomly chosen, obese children without the Arg64 allele (n = 35, male: 20). A significant difference was found between the body weight (81.2±23.2 vs 75.6±17.7kg; mean±s.d.; P

AB - Objective: To estimate the frequency of Arg64 allele of the β3-adrenergic receptor (3-BAR) gene in healthy (H) and obese (O) Hungarian children, and to look for possible associations between this polymorphism and some clinical and metabolic characteristics of obese children. Patients/methods: In all, 147 healthy (male: 68) and 295 obese (male: 168) children were examined. The average age of the children in the two groups was 12.4±1.7 vs 12.6±3.2, respectively. Exon 1 of 3-BAR was amplified by polymerase chain reaction and the fragments were digested with BstN1. In obese children, oral glucose tolerance test was carried out and blood pressure (BP) was checked. Results: The frequency of Trp64Arg polymorphism in normal and obese Hungarian children was similar (H vs O: n = 14/9.5% vs n = 35/11.8%). Obese children carrying the Arg64 allele (n = 35, male: 23) were compared to randomly chosen, obese children without the Arg64 allele (n = 35, male: 20). A significant difference was found between the body weight (81.2±23.2 vs 75.6±17.7kg; mean±s.d.; P

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