The frequency of leukemia and other malignant diseases was investigated with the help of questionnaires in the families of hospitalized children. Data were obtained from 1,722 relatives of 154 children born with congenital abnormalities, from 1,566 relatives of 151 children who experienced recurrent infections and from 931 relations of 88 epileptic children. Chi square significance tests between leukemia and tumor incidences were performed on 2 by 2 frequency tables of relatives for pairs of groups. The frequencies of malignancies among the relatives of children with recurrent infections was significantly higher than among the relatives of the other 2 groups. There might be a pathogenetic relationship between genetically controlled immune deficiency, susceptibility to infections and the occurrence of malignant tumors.
|Number of pages||7|
|Publication status||Published - Jan 1 1974|
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