The FluG-BrlA pathway contributes to the initialisation of autolysis in submerged Aspergillus nidulans cultures

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The fluG gene proved to be essential in the initialisation of autolysis in Aspergillus nidulans (teleomorph Emericella nidulans) cultures, while a loss-of-function mutation in only one out of the flbB-E genes had only minor effects on autolysis. In contrast to its important role in sporulation, brlA regulated only some, but not all, elements of the autolytic process. The tightly coupled autolytic events (chitinase and proteinase production, hyphal fragmentation, disorganisation of pellets, autolytic loss of biomass) observable in ageing cultures of A. nidulans were disconnected by loss-of-function mutations in some genes of the FluG-BrlA regulatory network. The tight correlation between pellet morphology and size and hydrolase production was also erased by these mutations. On the other hand, the mutations studied did not affect the glutathione metabolism of the fungus.

Original languageEnglish
Pages (from-to)757-763
Number of pages7
JournalMycological research
Volume109
Issue number7
DOIs
Publication statusPublished - Jul 2005

ASJC Scopus subject areas

  • Biotechnology
  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Plant Science

Fingerprint Dive into the research topics of 'The FluG-BrlA pathway contributes to the initialisation of autolysis in submerged Aspergillus nidulans cultures'. Together they form a unique fingerprint.

  • Cite this