The flow-function relationship in patients with chronic coronary artery disease and reduced regional function: A Doppler transesophageal and bidimensional transthoracic echocardiography study

Monica Baroni, Marco A. Torres, Stefano Maffei, Albert Varga, Marco Terrazzi, Andrea Biagini, Eugenio Picano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Infra-low dose dipyridamole allows one to selectively explore myocardial viability. Transesophageal echocardiography Doppler measurement of left anterior descending coronary artery flow at baseline and following dipyridamole is an efficient tool to assess coronary flow response. Aim of this study was to determine the flow-function relationship during coronary vasodilatory stress in patients with coronary artery disease and baseline dysfunction. Methods and results: Twelve patients with resting dyssynergies and 6 controls underwent assessment of regional function and of left anterior descending blood flow velocity. Flow and function were evaluated at rest and following infra-low dose dipyridamole (0.28 mg/Kg over 4 min). Controls showed a normal function at rest and after dipyridamole. Six patients ('Responders') with resting dyssynergies showed an improvement in segments of left anterior descending artery territory, whereas the other six ones ('Non-responders') showed no functional change. Controls and 'Responders' had similar values of resting peak diastolic left anterior descending artery flow velocity both at rest and after dipyridamole, whereas 'Non-responders' showed a blunted flow response to dipyridamole. Conclusion: Myocardial segments with a resting dysfunction and a contractile reserve more often exhibit a residual flow response, whereas segments with fixed pattern show a flat flow response during coronary vasodilator stress.

Original languageEnglish
Pages (from-to)271-278
Number of pages8
JournalInternational Journal of Cardiac Imaging
Volume15
Issue number4
DOIs
Publication statusPublished - Sep 3 1999

Keywords

  • Dipyridamole
  • Doppler
  • Myocardial viability
  • Transesophageal echocardiography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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