The first Swedish H1N2 swine influenza virus isolate represents an uncommon reassortant

A. Bálint, Giorgi Metreveli, Frederik Widén, Siamak Zohari, Mikael Berg, Mats Isaksson, Lena Hm Renström, Per Wallgren, Sándor Belák, Thomas Segall, István Kiss

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The European swine influenza viruses (SIVs) show considerable diversity comprising different types of H1N1, H3N2, and H1N2 strains. The intensifying full genome sequencing efforts reveal further reassortants within these subtypes. Here we report the identification of an uncommon reassortant variant of H1N2 subtype influenza virus isolated from a pig in a multisite herd where H1N2 swine influenza was diagnosed for the first time in Sweden during the winter of 2008-2009. The majority of the European H1N2 swine influenza viruses described so far possess haemagglutinin (HA) of the human-like H1N2 SIV viruses and the neuraminidase (NA) of either the European H1N2 or H3N2 SIV-like viruses. The Swedish isolate has an avian-like SIV HA and a H3N2 SIV-like NA, which is phylogenetically more closely related to H3N2 SIV NAs from isolates collected in the early '80s than to the NA of H3N2 origin of the H1N2 viruses isolated during the last decade, as depicted by some German strains, indicative of independent acquisition of the NA genes for these two types of reassortants. The internal genes proved to be entirely of avian-like SIV H1N1 origin. The prevalence of this SIV variant in pig populations needs to be determined, as well as the suitability of the routinely used laboratory reagents to analyze this strain. The description of this H1N2 SIV adds further information to influenza epidemiology and supports the necessity of surveillance for influenza viruses in pigs.

Original languageEnglish
Article number180
JournalVirology Journal
Volume6
DOIs
Publication statusPublished - 2009

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Orthomyxoviridae
Swine
Neuraminidase
Hemagglutinins
Human Influenza
H1N2 Subtype Influenza A Virus
Viruses
Sweden
Genes
Epidemiology
Genome

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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The first Swedish H1N2 swine influenza virus isolate represents an uncommon reassortant. / Bálint, A.; Metreveli, Giorgi; Widén, Frederik; Zohari, Siamak; Berg, Mikael; Isaksson, Mats; Renström, Lena Hm; Wallgren, Per; Belák, Sándor; Segall, Thomas; Kiss, István.

In: Virology Journal, Vol. 6, 180, 2009.

Research output: Contribution to journalArticle

Bálint, A, Metreveli, G, Widén, F, Zohari, S, Berg, M, Isaksson, M, Renström, LH, Wallgren, P, Belák, S, Segall, T & Kiss, I 2009, 'The first Swedish H1N2 swine influenza virus isolate represents an uncommon reassortant', Virology Journal, vol. 6, 180. https://doi.org/10.1186/1743-422X-6-180
Bálint, A. ; Metreveli, Giorgi ; Widén, Frederik ; Zohari, Siamak ; Berg, Mikael ; Isaksson, Mats ; Renström, Lena Hm ; Wallgren, Per ; Belák, Sándor ; Segall, Thomas ; Kiss, István. / The first Swedish H1N2 swine influenza virus isolate represents an uncommon reassortant. In: Virology Journal. 2009 ; Vol. 6.
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