The first Pd-catalyzed Buchwald–Hartwig aminations at C-2 or C-4 in the estrone series

Ildikó Bacsa, Dávid Szemerédi, J. Wölfling, Gyula Schneider, Lilla Fekete, E. Mernyák

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A facile Pd-catalyzed C(sp2)–N coupling to provide a range of 2- or 4-[(subst.)phenyl]amino-13α-estrone derivatives has been achieved under microwave irradiation. The reactions were mediated with the use of Pd(OAc)2 as a catalyst and KOt-Bu as a base in the presence of X-Phos as a ligand. The desired products have been obtained in good to excellent yields. The nature and the position of the aniline substituent at the aromatic ring influenced the outcome of the couplings. 2-Amino-13α-estrone was also synthesized in a two-step protocol including an amination of 2-bromo-13α-estrone 3-benzyl ether with benzophenone imine and subsequent hydrogenolysis.

Original languageEnglish
Pages (from-to)998-1003
Number of pages6
JournalBeilstein Journal of Organic Chemistry
Volume14
DOIs
Publication statusPublished - May 4 2018

Keywords

  • 13α-estrone
  • Aminoestrones
  • Buchwald–Hartwig amination
  • Functionalization
  • Microwave assisted reactions

ASJC Scopus subject areas

  • Organic Chemistry

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