The first complete genome sequence of a non-chicken aviadenovirus, proposed to be turkey adenovirus 1

Gyodouble acutezodouble acute L Kaján, Raymund Stefancsik, K. Ursu, Vilmos Palya, Mária Benkodouble acute

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The complete genome sequence of an adenovirus, isolated from turkey and proposed to be turkey adenovirus type 1 (TAdV-1), was determined to extend our knowledge about the genome organisation and phylogeny of aviadenoviruses. The longest adenovirus genome, consisting of 45,412. bp, with the highest G. +. C content (of 67.55%) known to date, was found. The central part of the TAdV-1 genome has the conserved gene set and arrangement that are characteristic for every other adenovirus analysed to date. This genome core is flanked by the terminal early regions 1 and 4 (E1 and E4). Aviadenovirus-specific genus-common genes were found in these regions, each containing nine such open reading frames (ORFs). Additionally a type-specific novel ORF, designated as ORF50, was found in E4. Phylogenetic analysis as well as the presence of the genus-specific genes, splice sites and protease cleavage sites confirmed the classification of TAdV-1 in the genus Aviadenovirus. Intrageneric analyses of two genus-specific genes demonstrated the distinctness of TAdV-1 from other aviadenoviruses, thus supporting the proposal for the establishment of a new species, Turkey adenovirus B for TAdV-1.

Original languageEnglish
Pages (from-to)226-233
Number of pages8
JournalVirus Research
Volume153
Issue number2
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Aviadenovirus
Adenoviridae
Genome
Open Reading Frames
Genes
Gene Order
Phylogeny
Turkey
Peptide Hydrolases

Keywords

  • DNA virus
  • Fowl
  • Genome analysis
  • Genome sequencing
  • Hungary
  • Turkey adenovirus B

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Cancer Research

Cite this

The first complete genome sequence of a non-chicken aviadenovirus, proposed to be turkey adenovirus 1. / Kaján, Gyodouble acutezodouble acute L; Stefancsik, Raymund; Ursu, K.; Palya, Vilmos; Benkodouble acute, Mária.

In: Virus Research, Vol. 153, No. 2, 11.2010, p. 226-233.

Research output: Contribution to journalArticle

Kaján, Gyodouble acutezodouble acute L ; Stefancsik, Raymund ; Ursu, K. ; Palya, Vilmos ; Benkodouble acute, Mária. / The first complete genome sequence of a non-chicken aviadenovirus, proposed to be turkey adenovirus 1. In: Virus Research. 2010 ; Vol. 153, No. 2. pp. 226-233.
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