The first characterized carbapenem-resistant Bacteroides fragilis strain from Croatia and the case study for IT

Maja Bogdan, Ljilijana Perić, Katalin Ördög, Dubravka Vuković, E. Urbán, J. Sóki

Research output: Contribution to journalArticle

Abstract

An imipenem-resistant Bacteroides fragilis strain was isolated from the blood of a 72-year-old male patient with a urinary bladder tumor in Osijek, Croatia. This strain was also resistant to ampicillin, piperacillin/tazobactam, cefoxitin, clindamycin, tetracycline, and harbored cfiA, ermF, and tetQ genes where the high-level expression of the cfiA carbapenem-resistant gene was driven by an IS1187 element. Interestingly, despite the carbapenem-resistant feature of the B. fragilis from blood, the patient relatively easily recovered from the bacteremia. It was the first characterized imipenem-resistant B. fragilis isolate with its case report from Croatia, which confirmed the appearance of carbapenem-resistant B. fragilis strains, that continues worldwide with low incidence and the molecular characteristics vary temporally and geographically.

Original languageEnglish
Pages (from-to)317-323
Number of pages7
JournalActa Microbiologica et Immunologica Hungarica
Volume65
Issue number3
DOIs
Publication statusPublished - Aug 1 2018

Fingerprint

Bacteroides fragilis
Croatia
Carbapenems
Imipenem
Cefoxitin
Clindamycin
Ampicillin
Bacteremia
Tetracycline
Urinary Bladder Neoplasms
Genes
Urinary Bladder
Incidence

Keywords

  • B. fragilis
  • Carbapenem resistance
  • Ertapenem
  • Imipenem
  • IS1187

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

The first characterized carbapenem-resistant Bacteroides fragilis strain from Croatia and the case study for IT. / Bogdan, Maja; Perić, Ljilijana; Ördög, Katalin; Vuković, Dubravka; Urbán, E.; Sóki, J.

In: Acta Microbiologica et Immunologica Hungarica, Vol. 65, No. 3, 01.08.2018, p. 317-323.

Research output: Contribution to journalArticle

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