The expression of cytoskeleton regulatory protein Mena in colorectal lesions

Simona Gurzu, I. Jung, I. Prantner, I. Ember, Z. Pávai, T. Mezei

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The actin regulatory proteins Ena/VASP (Enabled/Vasodilator stimulated phosphoprotein) family is involved in the control of cell motility and adhesion. They are important in the actin-dependent processes where dynamic actin reorganization it is necessary. The deregulation of actin cycle could have an important role in the cells' malignant transformation, tumor invasion or metastasis. Recently studies revealed that the human orthologue of murine Mena is modulated during the breast carcinogenesis. In our study, we tried to observe the immunohistochemical expression of mammalian Ena (Mena) in the colorectal polyps and carcinomas. We analyzed 10 adenomatous polyps (five with dysplasia) and 36 adenocarcinomas. We used the indirect immunoperoxidase staining. BD Biosciences have provided the Mena antibody. We observed that Mena was not expressed in the normal colorectal mucosa neither in polyps without dysplasia, but its expression was very high in polyps with high dysplasia. In colorectal carcinomas, Mena marked the tumoral cells in 80% of cases. In 25% of positive cases, the intensity was 3+, in 60% 2+ and in the other 15% 1+. The Mena intensity was higher in the microsatellite stable tumors (MSS) and was correlated with vascular invasion, with intensity of angiogenesis marked with CD31 and CD105 and with c-erbB-2 and p53 expression. This is the first study in the literature about Mena expression in colorectal lesions.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalRomanian Journal of Morphology and Embryology
Volume49
Issue number3
Publication statusPublished - Dec 1 2008

Keywords

  • Angiogenesis
  • Colorectal carcinomas
  • Mena immunostain
  • Microsatellite instability

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Embryology
  • Developmental Biology
  • Cell Biology

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