The exocrine pancreas: The acinar-ductal tango in physiology and pathophysiology

Peter Hegyi, Ole H. Petersen

Research output: Chapter in Book/Report/Conference proceedingChapter

59 Citations (Scopus)

Abstract

There are many reviews of pancreatic acinar cell function and also of pancreatic duct function, but there is an almost total absence of synthetic reviews bringing the integrated functions of these two vitally and mutually interdependent cells together. This is what we have attempted to do in this chapter. In the first part, we review the normal integrated function of the acinar-ductal system, with particular emphasis on how regulation of one type of cell also influences the other cell type. In the second part, we review a range of pathological processes, particularly those involved in acute pancreatitis (AP), an often-fatal human disease in which the pancreas digests itself, in order to explore how malfunction of one of the cell types adversely affects the function of the other.

Original languageEnglish
Title of host publicationReviews of Physiology, Biochemistry and Pharmacology
PublisherSpringer Verlag
Pages1-30
Number of pages30
ISBN (Print)9783319009988
DOIs
Publication statusPublished - Jan 1 2013

Publication series

NameReviews of Physiology, Biochemistry and Pharmacology
Volume165
ISSN (Print)0303-4240
ISSN (Electronic)1617-5786

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'The exocrine pancreas: The acinar-ductal tango in physiology and pathophysiology'. Together they form a unique fingerprint.

  • Cite this

    Hegyi, P., & Petersen, O. H. (2013). The exocrine pancreas: The acinar-ductal tango in physiology and pathophysiology. In Reviews of Physiology, Biochemistry and Pharmacology (pp. 1-30). (Reviews of Physiology, Biochemistry and Pharmacology; Vol. 165). Springer Verlag. https://doi.org/10.1007/112_2013_14