The exocrine pancreas: The acinar-ductal tango in physiology and pathophysiology

P. Hegyi, Ole H. Petersen

Research output: Chapter in Book/Report/Conference proceedingChapter

58 Citations (Scopus)

Abstract

There are many reviews of pancreatic acinar cell function and also of pancreatic duct function, but there is an almost total absence of synthetic reviews bringing the integrated functions of these two vitally and mutually interdependent cells together. This is what we have attempted to do in this chapter. In the first part, we review the normal integrated function of the acinar-ductal system, with particular emphasis on how regulation of one type of cell also influences the other cell type. In the second part, we review a range of pathological processes, particularly those involved in acute pancreatitis (AP), an often-fatal human disease in which the pancreas digests itself, in order to explore how malfunction of one of the cell types adversely affects the function of the other.

Original languageEnglish
Title of host publicationReviews of Physiology, Biochemistry and Pharmacology
PublisherSpringer Verlag
Pages1-30
Number of pages30
Volume165
ISBN (Print)9783319009988
DOIs
Publication statusPublished - 2013

Publication series

NameReviews of Physiology, Biochemistry and Pharmacology
Volume165
ISSN (Print)03034240
ISSN (Electronic)16175786

Fingerprint

Exocrine Pancreas
Physiology
Acinar Cells
Pancreatic Ducts
Pathologic Processes
Pancreatitis
Pancreas
Ducts

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Physiology (medical)
  • Pharmacology
  • Medicine(all)

Cite this

Hegyi, P., & Petersen, O. H. (2013). The exocrine pancreas: The acinar-ductal tango in physiology and pathophysiology. In Reviews of Physiology, Biochemistry and Pharmacology (Vol. 165, pp. 1-30). (Reviews of Physiology, Biochemistry and Pharmacology; Vol. 165). Springer Verlag. https://doi.org/10.1007/112_2013_14

The exocrine pancreas : The acinar-ductal tango in physiology and pathophysiology. / Hegyi, P.; Petersen, Ole H.

Reviews of Physiology, Biochemistry and Pharmacology. Vol. 165 Springer Verlag, 2013. p. 1-30 (Reviews of Physiology, Biochemistry and Pharmacology; Vol. 165).

Research output: Chapter in Book/Report/Conference proceedingChapter

Hegyi, P & Petersen, OH 2013, The exocrine pancreas: The acinar-ductal tango in physiology and pathophysiology. in Reviews of Physiology, Biochemistry and Pharmacology. vol. 165, Reviews of Physiology, Biochemistry and Pharmacology, vol. 165, Springer Verlag, pp. 1-30. https://doi.org/10.1007/112_2013_14
Hegyi P, Petersen OH. The exocrine pancreas: The acinar-ductal tango in physiology and pathophysiology. In Reviews of Physiology, Biochemistry and Pharmacology. Vol. 165. Springer Verlag. 2013. p. 1-30. (Reviews of Physiology, Biochemistry and Pharmacology). https://doi.org/10.1007/112_2013_14
Hegyi, P. ; Petersen, Ole H. / The exocrine pancreas : The acinar-ductal tango in physiology and pathophysiology. Reviews of Physiology, Biochemistry and Pharmacology. Vol. 165 Springer Verlag, 2013. pp. 1-30 (Reviews of Physiology, Biochemistry and Pharmacology).
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