The evolutionary relationship among Caucasian MS patients and controls

B. Kalman, H. Alder, U. F. Bosch, F. D. Lublin, D. Chatterjee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Previous observations suggest that the mitochondrial (mt)DNA may confer susceptibility to multiple sclerosis (MS). However, the proportion of affected individuals and the range of contributing mtDNA abnormalities are unknown. To help clarify this question, we analyzed the first hypervariable D-loop sequences of the mtDNA in a group of randomly selected Caucasian MS patients, in MS patients with prominent optic neuritis (PON) and in controls. Phylogenetic analysis of these D-loop sequences revealed that individuals in both groups of patients are generally scattered in the Caucasian phytogeny. However, a small duster of unrelated MS patients identified by this analysis suggests that a maternal lineage with MS relevant mtDNA sequences may exist, and merits a more comprehensive study.

Original languageEnglish
Pages (from-to)288-295
Number of pages8
JournalMultiple Sclerosis
Volume1
Issue number5
DOIs
Publication statusPublished - Jan 1 1996

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Keywords

  • Genetic relationship
  • Mitochondrial DNA

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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