The evolution of the calpain family as reflected in paralogous chromosome regions

Gáspár Jékely, Peter Friedrich

Research output: Contribution to journalArticle

37 Citations (Scopus)


Calpains, the Ca2+-dependent intracellular proteinases, are involved in the regulation of distinct cellular pathways including signal transduction and processing, cytoskeleton dynamics, and muscle homeostasis. To investigate the evolutionary origin of diverse calpain subfamilies, a phylogenetic study was carried out. The topology of the calpain phylogenetic tree has shown that some of the gene duplications occurred before the divergence of the protostome and deuterostome lineages. Other gene doublings, leading to vertebrate-specific calpain forms, took place during early chordate evolution and coincided with genome duplications as disclosed by the localization of calpain genes to paralogous chromosome regions in the human genome. On the basis of the phylogenetic tree, the time of gene duplications, and the localization of calpain genes, we propose a model of tandem and chromosome duplications for the evolution of vertebrate-specific calpain forms. The data presented here are consistent with scenarios proposed for the evolution of other multigene families.

Original languageEnglish
Pages (from-to)272-281
Number of pages10
JournalJournal of Molecular Evolution
Issue number2
Publication statusPublished - Aug 9 1999


  • Calpain
  • Chordate evolution
  • Gene duplication
  • Paralogous chromosome regions
  • Tetraploidization

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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