The evidence for and against different modes of tumour cell extravasation in the lung: diapedesis, capillary destruction, necroptosis, and endothelialization

Sándor Paku, Viktoria Laszlo, Katalin Dezso, Peter Nagy, Mir Alireza Hoda, Walter Klepetko, Ferenc Renyi-Vamos, Jozsef Timar, Andrew R. Reynolds, B. Döme

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The development of lung metastasis is a significant negative prognostic factor for cancer patients. The extravasation phase of lung metastasis involves interactions of tumour cells with the pulmonary endothelium. These interactions may have broad biological and medical significance, with potential clinical implications ranging from the discovery of lung metastasis biomarkers to the identification of targets for intervention in preventing lung metastases. Because of the potential significance, the mechanisms of tumour cell extravasation require cautious, systematic studies. Here, we discuss the literature pertaining to the proposed mechanisms of extravasation and critically compare a recently proposed mechanism (tumour cell-induced endothelial necroptosis) with the already described extravasation mechanisms in the lung. We also provide novel data that may help to explain the underlying physiological basis for endothelialization as a mechanism of tumour cell extravasation in the lung.

Original languageEnglish
Pages (from-to)441-447
Number of pages7
JournalJournal of Pathology
Volume241
Issue number4
DOIs
Publication statusPublished - Mar 1 2017

Keywords

  • endothelialization
  • extravasation
  • lung
  • metastasis
  • necroptosis
  • tumour cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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