The evaluation of screening and early detection strategies for type 2 diabetes and impaired glucose tolerance (DETECT-2) update of the finnish diabetes risk score for prediction of incident type 2 diabetes

M. Alssema, D. Vistisen, M. W. Heymans, G. Nijpels, C. Glümer, P. Z. Zimmet, J. E. Shaw, M. Eliasson, C. D A Stehouwer, A. Tabák, S. Colagiuri, K. Borch-Johnsen, J. M. Dekker

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Aims/hypothesis: The Finnish diabetes risk questionnaire is a widely used, simple tool for identification of those at risk for drug-treated type 2 diabetes. We updated the risk questionnaire by using clinically diagnosed and screen-detected type 2 diabetes instead of drug-treated diabetes as an endpoint and by considering additional predictors. Methods: Data from 18,301 participants in studies of the Evaluation of Screening and Early Detection Strategies for Type 2 Diabetes and Impaired Glucose Tolerance (DETECT-2) project with baseline and follow-up information on oral glucose tolerance status were included. Incidence of type 2 diabetes within 5 years was used as the outcome variable. Improvement in discrimination and classification of the logistic regression model was assessed by the area under the receiver-operating characteristic (ROC) curve and by the net reclassification improvement. Internal validation was by bootstrapping techniques. Results: Of the 18,301 participants, 844 developed type 2 diabetes in a period of 5 years (4.6%). The Finnish risk score had an area under the ROC curve of 0.742 (95% CI 0.726-0.758). Re-estimation of the regression coefficients improved the area under the ROC curve to 0.766 (95% CI 0.750-0.783). Additional items such as male sex, smoking and family history of diabetes (parent, sibling or both) improved the area under the ROC curve and net reclassification. Bootstrapping showed good internal validity. Conclusions/interpretation: The predictive value of the original Finnish risk questionnaire could be improved by adding information on sex, smoking and family history of diabetes. The DETECT-2 update of the Finnish diabetes risk questionnaire is an adequate and robust predictor for future screen-detected and clinically diagnosed type 2 diabetes in Europid populations.

Original languageEnglish
Pages (from-to)1004-1012
Number of pages9
JournalDiabetologia
Volume54
Issue number5
DOIs
Publication statusPublished - May 2011

Fingerprint

Glucose Intolerance
Type 2 Diabetes Mellitus
ROC Curve
Logistic Models
Smoking
Glucose Tolerance Test
Pharmaceutical Preparations
Surveys and Questionnaires
Incidence
Population

Keywords

  • Epidemiology
  • Incidence
  • Prediction model
  • Primary prevention
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

The evaluation of screening and early detection strategies for type 2 diabetes and impaired glucose tolerance (DETECT-2) update of the finnish diabetes risk score for prediction of incident type 2 diabetes. / Alssema, M.; Vistisen, D.; Heymans, M. W.; Nijpels, G.; Glümer, C.; Zimmet, P. Z.; Shaw, J. E.; Eliasson, M.; Stehouwer, C. D A; Tabák, A.; Colagiuri, S.; Borch-Johnsen, K.; Dekker, J. M.

In: Diabetologia, Vol. 54, No. 5, 05.2011, p. 1004-1012.

Research output: Contribution to journalArticle

Alssema, M, Vistisen, D, Heymans, MW, Nijpels, G, Glümer, C, Zimmet, PZ, Shaw, JE, Eliasson, M, Stehouwer, CDA, Tabák, A, Colagiuri, S, Borch-Johnsen, K & Dekker, JM 2011, 'The evaluation of screening and early detection strategies for type 2 diabetes and impaired glucose tolerance (DETECT-2) update of the finnish diabetes risk score for prediction of incident type 2 diabetes', Diabetologia, vol. 54, no. 5, pp. 1004-1012. https://doi.org/10.1007/s00125-010-1990-7
Alssema, M. ; Vistisen, D. ; Heymans, M. W. ; Nijpels, G. ; Glümer, C. ; Zimmet, P. Z. ; Shaw, J. E. ; Eliasson, M. ; Stehouwer, C. D A ; Tabák, A. ; Colagiuri, S. ; Borch-Johnsen, K. ; Dekker, J. M. / The evaluation of screening and early detection strategies for type 2 diabetes and impaired glucose tolerance (DETECT-2) update of the finnish diabetes risk score for prediction of incident type 2 diabetes. In: Diabetologia. 2011 ; Vol. 54, No. 5. pp. 1004-1012.
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AU - Glümer, C.

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