The EvA study: Aims and strategy

Loems Ziegler-Heitbrock, Marion Frankenberger, Irene Heimbeck, Dorothe Burggraf, Matthias Wjst, Karl Häussinger, Chris Brightling, Sumit Gupta, David Parr, Deepak Subramanian, Dave Singh, Umme Kolsum, Piera Boschetto, Alfredo Potena, Dorota Gorecka, Adam Nowinski, Imre Barta, Balazs Döme, Janos Strausz, Timm GreulichClaus Vogelmeier, Robert Bals, Jens M. Hohlfeld, Tobias Welte, Per Venge, Ivo Gut, Anne Boland, Robert Olaso, Jörg Hager, Pieter Hiemstra, Klaus F. Rabe, Martina Unmußig, Joachim Müller-Quernheim, Antje Prasse

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The EvA study is a European Union-funded project under the Seventh Framework Programme (FP7), which aims at defining new markers for chronic obstructive pulmonary disease (COPD) and its subtypes. The acronym is derived from emphysema versus airway disease, indicating that the project targets these two main phenotypes of the disease. The EvA study is based on the concept that emphysema and airway disease are governed by different pathophysiological processes, are driven by different genes and have differential gene expression in the lung. To define these genes, patients and non-COPD controls are recruited for clinical examination, lung function analysis and computed tomography (CT) of the lung. CT scans are used to define the phenotypes based on lung density and airway wall thickness. This is followed by bronchoscopy in order to obtain samples from the airways and the alveoli. These tissue samples, along with blood samples, are then subjected to genome-wide expression and association analysis and markers linked to the phenotypes are identified. The population of the EvA study is different from other COPD study populations, since patients with current oral glucocorticoids, antibiotics and exacerbations or current smokers are excluded, such that the signals detected in the molecular analysis are due to the distinct inflammatory process of emphysema and airway disease in COPD. Copyright

Original languageEnglish
Pages (from-to)823-829
Number of pages7
JournalEuropean Respiratory Journal
Volume40
Issue number4
DOIs
Publication statusPublished - Oct 1 2012

Keywords

  • Airway inflammation
  • Bronchoalveloar lavage
  • Computed tomography
  • Emphysema

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Ziegler-Heitbrock, L., Frankenberger, M., Heimbeck, I., Burggraf, D., Wjst, M., Häussinger, K., Brightling, C., Gupta, S., Parr, D., Subramanian, D., Singh, D., Kolsum, U., Boschetto, P., Potena, A., Gorecka, D., Nowinski, A., Barta, I., Döme, B., Strausz, J., ... Prasse, A. (2012). The EvA study: Aims and strategy. European Respiratory Journal, 40(4), 823-829. https://doi.org/10.1183/09031936.00142811