The eukaryotic linear motif resource - 2018 update

Marc Gouw, Sushama Michael, Hugo Sámano-Sánchez, Manjeet Kumar, András Zeke, Benjamin Lang, Benoit Bely, Lucía B. Chemes, Norman E. Davey, Ziqi Deng, Francesca Diella, Clara Marie Gürth, Ann Kathrin Huber, Stefan Kleinsorg, Lara S. Schlegel, Nicolás Palopoli, Kim V. Roey, Brigitte Altenberg, A. Reményi, Holger DinkelToby J. Gibson

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif (ELM) resource (elm.eu.org) is dedicated to SLiMs, consisting of a manually curated database of over 275 motif classes and over 3000 motif instances, and a pipeline to discover candidate SLiMs in protein sequences. For 15 years, ELM has been one of the major resources for motif research. In this database update, we present the latest additions to the database including 32 new motif classes, and new features including Uniprot and Reactome integration. Finally, to help provide cellular context, we present some biological insights about SLiMs in the cell cycle, as targets for bacterial pathogenicity and their functionality in the human kinome.

Original languageEnglish
Pages (from-to)D428-D434
JournalNucleic Acids Research
Volume46
Issue numberD1
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Databases
Amino Acid Motifs
Protein Binding
Virulence
Cell Cycle
Research

ASJC Scopus subject areas

  • Genetics

Cite this

Gouw, M., Michael, S., Sámano-Sánchez, H., Kumar, M., Zeke, A., Lang, B., ... Gibson, T. J. (2018). The eukaryotic linear motif resource - 2018 update. Nucleic Acids Research, 46(D1), D428-D434. https://doi.org/10.1093/nar/gkx1077

The eukaryotic linear motif resource - 2018 update. / Gouw, Marc; Michael, Sushama; Sámano-Sánchez, Hugo; Kumar, Manjeet; Zeke, András; Lang, Benjamin; Bely, Benoit; Chemes, Lucía B.; Davey, Norman E.; Deng, Ziqi; Diella, Francesca; Gürth, Clara Marie; Huber, Ann Kathrin; Kleinsorg, Stefan; Schlegel, Lara S.; Palopoli, Nicolás; Roey, Kim V.; Altenberg, Brigitte; Reményi, A.; Dinkel, Holger; Gibson, Toby J.

In: Nucleic Acids Research, Vol. 46, No. D1, 01.01.2018, p. D428-D434.

Research output: Contribution to journalArticle

Gouw, M, Michael, S, Sámano-Sánchez, H, Kumar, M, Zeke, A, Lang, B, Bely, B, Chemes, LB, Davey, NE, Deng, Z, Diella, F, Gürth, CM, Huber, AK, Kleinsorg, S, Schlegel, LS, Palopoli, N, Roey, KV, Altenberg, B, Reményi, A, Dinkel, H & Gibson, TJ 2018, 'The eukaryotic linear motif resource - 2018 update', Nucleic Acids Research, vol. 46, no. D1, pp. D428-D434. https://doi.org/10.1093/nar/gkx1077
Gouw M, Michael S, Sámano-Sánchez H, Kumar M, Zeke A, Lang B et al. The eukaryotic linear motif resource - 2018 update. Nucleic Acids Research. 2018 Jan 1;46(D1):D428-D434. https://doi.org/10.1093/nar/gkx1077
Gouw, Marc ; Michael, Sushama ; Sámano-Sánchez, Hugo ; Kumar, Manjeet ; Zeke, András ; Lang, Benjamin ; Bely, Benoit ; Chemes, Lucía B. ; Davey, Norman E. ; Deng, Ziqi ; Diella, Francesca ; Gürth, Clara Marie ; Huber, Ann Kathrin ; Kleinsorg, Stefan ; Schlegel, Lara S. ; Palopoli, Nicolás ; Roey, Kim V. ; Altenberg, Brigitte ; Reményi, A. ; Dinkel, Holger ; Gibson, Toby J. / The eukaryotic linear motif resource - 2018 update. In: Nucleic Acids Research. 2018 ; Vol. 46, No. D1. pp. D428-D434.
@article{519b303ec43f4881abd8716420630d7e,
title = "The eukaryotic linear motif resource - 2018 update",
abstract = "Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif (ELM) resource (elm.eu.org) is dedicated to SLiMs, consisting of a manually curated database of over 275 motif classes and over 3000 motif instances, and a pipeline to discover candidate SLiMs in protein sequences. For 15 years, ELM has been one of the major resources for motif research. In this database update, we present the latest additions to the database including 32 new motif classes, and new features including Uniprot and Reactome integration. Finally, to help provide cellular context, we present some biological insights about SLiMs in the cell cycle, as targets for bacterial pathogenicity and their functionality in the human kinome.",
author = "Marc Gouw and Sushama Michael and Hugo S{\'a}mano-S{\'a}nchez and Manjeet Kumar and Andr{\'a}s Zeke and Benjamin Lang and Benoit Bely and Chemes, {Luc{\'i}a B.} and Davey, {Norman E.} and Ziqi Deng and Francesca Diella and G{\"u}rth, {Clara Marie} and Huber, {Ann Kathrin} and Stefan Kleinsorg and Schlegel, {Lara S.} and Nicol{\'a}s Palopoli and Roey, {Kim V.} and Brigitte Altenberg and A. Rem{\'e}nyi and Holger Dinkel and Gibson, {Toby J.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1093/nar/gkx1077",
language = "English",
volume = "46",
pages = "D428--D434",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "D1",

}

TY - JOUR

T1 - The eukaryotic linear motif resource - 2018 update

AU - Gouw, Marc

AU - Michael, Sushama

AU - Sámano-Sánchez, Hugo

AU - Kumar, Manjeet

AU - Zeke, András

AU - Lang, Benjamin

AU - Bely, Benoit

AU - Chemes, Lucía B.

AU - Davey, Norman E.

AU - Deng, Ziqi

AU - Diella, Francesca

AU - Gürth, Clara Marie

AU - Huber, Ann Kathrin

AU - Kleinsorg, Stefan

AU - Schlegel, Lara S.

AU - Palopoli, Nicolás

AU - Roey, Kim V.

AU - Altenberg, Brigitte

AU - Reményi, A.

AU - Dinkel, Holger

AU - Gibson, Toby J.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif (ELM) resource (elm.eu.org) is dedicated to SLiMs, consisting of a manually curated database of over 275 motif classes and over 3000 motif instances, and a pipeline to discover candidate SLiMs in protein sequences. For 15 years, ELM has been one of the major resources for motif research. In this database update, we present the latest additions to the database including 32 new motif classes, and new features including Uniprot and Reactome integration. Finally, to help provide cellular context, we present some biological insights about SLiMs in the cell cycle, as targets for bacterial pathogenicity and their functionality in the human kinome.

AB - Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif (ELM) resource (elm.eu.org) is dedicated to SLiMs, consisting of a manually curated database of over 275 motif classes and over 3000 motif instances, and a pipeline to discover candidate SLiMs in protein sequences. For 15 years, ELM has been one of the major resources for motif research. In this database update, we present the latest additions to the database including 32 new motif classes, and new features including Uniprot and Reactome integration. Finally, to help provide cellular context, we present some biological insights about SLiMs in the cell cycle, as targets for bacterial pathogenicity and their functionality in the human kinome.

UR - http://www.scopus.com/inward/record.url?scp=85040933008&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040933008&partnerID=8YFLogxK

U2 - 10.1093/nar/gkx1077

DO - 10.1093/nar/gkx1077

M3 - Article

AN - SCOPUS:85040933008

VL - 46

SP - D428-D434

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - D1

ER -