The environmental obesogen bisphenol A increases macrophage self-renewal

Grace Ampem, Alexandra Junginger, Haidong Yu, L. Balogh, Julianna Thuróczy, Marion E. Schneider, Tamás Röszer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Self-renewal of macrophages is important for the healthy development and replenishment of tissue-resident macrophage pools. How this mechanism is controlled by endocrine signals is still largely unexplored. Here, we show that the endocrine disruptor bisphenol A (BPA) increases macrophage self-renewal. This effect was associated with phosphorylation of extracellular signal-regulated kinase (ERK) and a slight increase in the expression of liver X receptor alpha (LXRα). We found that LXRα inhibition induced, while LXRα activation impeded, macrophage self-renewal. LXRα signaling hence may protect from excessive macrophage expansion. Self-renewing macrophages, however, had negligible LXRα expression when compared with quiescent macrophages. Accordingly, tissue-resident macrophage pools, which are dominated by quiescent macrophages, were rich in LXRα-expressing macrophages. Overall, we show that BPA increases macrophage self-renewal and that this effect, at least in part, can be inhibited by increasing LXRα expression. Since BPA is accumulated in the adipose tissue, it has the potential to increase self-renewal of adipose tissue macrophages, leading to a condition that might negatively impact adipose tissue health.

Original languageEnglish
JournalCell And Tissue Research
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Macrophages
Adipose Tissue
bisphenol A
Endocrine Disruptors
Macrophage Activation
Extracellular Signal-Regulated MAP Kinases
Liver X Receptors
Phosphorylation
Health

Keywords

  • Endocrine disruptors
  • ERK
  • LXR
  • Obesity
  • Obesogens

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

The environmental obesogen bisphenol A increases macrophage self-renewal. / Ampem, Grace; Junginger, Alexandra; Yu, Haidong; Balogh, L.; Thuróczy, Julianna; Schneider, Marion E.; Röszer, Tamás.

In: Cell And Tissue Research, 01.01.2019.

Research output: Contribution to journalArticle

Ampem, Grace ; Junginger, Alexandra ; Yu, Haidong ; Balogh, L. ; Thuróczy, Julianna ; Schneider, Marion E. ; Röszer, Tamás. / The environmental obesogen bisphenol A increases macrophage self-renewal. In: Cell And Tissue Research. 2019.
@article{8ad77787419943d087a1a8afcd5b333a,
title = "The environmental obesogen bisphenol A increases macrophage self-renewal",
abstract = "Self-renewal of macrophages is important for the healthy development and replenishment of tissue-resident macrophage pools. How this mechanism is controlled by endocrine signals is still largely unexplored. Here, we show that the endocrine disruptor bisphenol A (BPA) increases macrophage self-renewal. This effect was associated with phosphorylation of extracellular signal-regulated kinase (ERK) and a slight increase in the expression of liver X receptor alpha (LXRα). We found that LXRα inhibition induced, while LXRα activation impeded, macrophage self-renewal. LXRα signaling hence may protect from excessive macrophage expansion. Self-renewing macrophages, however, had negligible LXRα expression when compared with quiescent macrophages. Accordingly, tissue-resident macrophage pools, which are dominated by quiescent macrophages, were rich in LXRα-expressing macrophages. Overall, we show that BPA increases macrophage self-renewal and that this effect, at least in part, can be inhibited by increasing LXRα expression. Since BPA is accumulated in the adipose tissue, it has the potential to increase self-renewal of adipose tissue macrophages, leading to a condition that might negatively impact adipose tissue health.",
keywords = "Endocrine disruptors, ERK, LXR, Obesity, Obesogens",
author = "Grace Ampem and Alexandra Junginger and Haidong Yu and L. Balogh and Julianna Thur{\'o}czy and Schneider, {Marion E.} and Tam{\'a}s R{\"o}szer",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00441-019-03019-5",
language = "English",
journal = "Cell and Tissue Research",
issn = "0302-766X",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - The environmental obesogen bisphenol A increases macrophage self-renewal

AU - Ampem, Grace

AU - Junginger, Alexandra

AU - Yu, Haidong

AU - Balogh, L.

AU - Thuróczy, Julianna

AU - Schneider, Marion E.

AU - Röszer, Tamás

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Self-renewal of macrophages is important for the healthy development and replenishment of tissue-resident macrophage pools. How this mechanism is controlled by endocrine signals is still largely unexplored. Here, we show that the endocrine disruptor bisphenol A (BPA) increases macrophage self-renewal. This effect was associated with phosphorylation of extracellular signal-regulated kinase (ERK) and a slight increase in the expression of liver X receptor alpha (LXRα). We found that LXRα inhibition induced, while LXRα activation impeded, macrophage self-renewal. LXRα signaling hence may protect from excessive macrophage expansion. Self-renewing macrophages, however, had negligible LXRα expression when compared with quiescent macrophages. Accordingly, tissue-resident macrophage pools, which are dominated by quiescent macrophages, were rich in LXRα-expressing macrophages. Overall, we show that BPA increases macrophage self-renewal and that this effect, at least in part, can be inhibited by increasing LXRα expression. Since BPA is accumulated in the adipose tissue, it has the potential to increase self-renewal of adipose tissue macrophages, leading to a condition that might negatively impact adipose tissue health.

AB - Self-renewal of macrophages is important for the healthy development and replenishment of tissue-resident macrophage pools. How this mechanism is controlled by endocrine signals is still largely unexplored. Here, we show that the endocrine disruptor bisphenol A (BPA) increases macrophage self-renewal. This effect was associated with phosphorylation of extracellular signal-regulated kinase (ERK) and a slight increase in the expression of liver X receptor alpha (LXRα). We found that LXRα inhibition induced, while LXRα activation impeded, macrophage self-renewal. LXRα signaling hence may protect from excessive macrophage expansion. Self-renewing macrophages, however, had negligible LXRα expression when compared with quiescent macrophages. Accordingly, tissue-resident macrophage pools, which are dominated by quiescent macrophages, were rich in LXRα-expressing macrophages. Overall, we show that BPA increases macrophage self-renewal and that this effect, at least in part, can be inhibited by increasing LXRα expression. Since BPA is accumulated in the adipose tissue, it has the potential to increase self-renewal of adipose tissue macrophages, leading to a condition that might negatively impact adipose tissue health.

KW - Endocrine disruptors

KW - ERK

KW - LXR

KW - Obesity

KW - Obesogens

UR - http://www.scopus.com/inward/record.url?scp=85064700512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064700512&partnerID=8YFLogxK

U2 - 10.1007/s00441-019-03019-5

DO - 10.1007/s00441-019-03019-5

M3 - Article

AN - SCOPUS:85064700512

JO - Cell and Tissue Research

JF - Cell and Tissue Research

SN - 0302-766X

ER -