The enhancement of diazepam and muscimol binding by pentobarbital and (+)-etomidate: size of the molecular arrangement estimated by electron irradiation inactivation of rat cortex

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Abstract

Synaptosomal membranes were prepared from frozen rat cortices irradiated by 10 MeV electrons and the enhancement of [3H]diazepam and [3H]muscimol binding by pentobarbital (PB) and (+)-etomidate was studied. The target sizes of the corresponding parts of the receptor complex were estimated from the decrease in the enhancement as a function of irradiation dose. Different radiation inactivation constants suggest different regulatory units for the enhancement by PB and (+)-etomidate. Target sizes for PB and (+)-etomidate enhancement of [3H]diazepam binding were 127±14 and 360 + 124 kDa, respectively.

Original languageEnglish
Pages (from-to)116-120
Number of pages5
JournalNeuroscience Letters
Volume70
Issue number1
DOIs
Publication statusPublished - Sep 25 1986

Keywords

  • (+)-Etomidate
  • Enhancement of binding
  • Pentobarbital
  • Rat brain
  • Target size analysis
  • γ-Aminobutyric acid/benzodiazepine receptor complex

ASJC Scopus subject areas

  • Neuroscience(all)

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