The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities

T. Bíró, Balázs I. Tóth, G. Haskó, Ralf Paus, Pál Pacher

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

The newly discovered endocannabinoid system (ECS; comprising the endogenous lipid mediators endocannabinoids present in virtually all tissues, their G-protein-coupled cannabinoid receptors, biosynthetic pathways and metabolizing enzymes) has been implicated in multiple regulatory functions both in health and disease. Recent studies have intriguingly suggested the existence of a functional ECS in the skin and implicated it in various biological processes (e.g. proliferation, growth, differentiation, apoptosis and cytokine, mediator or hormone production of various cell types of the skin and appendages, such as the hair follicle and sebaceous gland). It seems that the main physiological function of the cutaneous ECS is to constitutively control the proper and well-balanced proliferation, differentiation and survival, as well as immune competence and/or tolerance, of skin cells. The disruption of this delicate balance might facilitate the development of multiple pathological conditions and diseases of the skin (e.g. acne, seborrhea, allergic dermatitis, itch and pain, psoriasis, hair growth disorders, systemic sclerosis and cancer).

Original languageEnglish
Pages (from-to)411-420
Number of pages10
JournalTrends in Pharmacological Sciences
Volume30
Issue number8
DOIs
Publication statusPublished - Aug 2009

Fingerprint

Endocannabinoids
Skin
Health
Dermatitis
Growth Disorders
Seborrheic Dermatitis
Biological Phenomena
Sebaceous Glands
Cannabinoid Receptors
Hair Follicle
Systemic Scleroderma
Biosynthetic Pathways
Acne Vulgaris
Therapeutics
G-Protein-Coupled Receptors
Psoriasis
GTP-Binding Proteins
Skin Diseases
Hair
Mental Competency

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

The endocannabinoid system of the skin in health and disease : novel perspectives and therapeutic opportunities. / Bíró, T.; Tóth, Balázs I.; Haskó, G.; Paus, Ralf; Pacher, Pál.

In: Trends in Pharmacological Sciences, Vol. 30, No. 8, 08.2009, p. 411-420.

Research output: Contribution to journalArticle

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